Effect of the Central Nervous System on Mucosal Growth and Apoptosis in the Small Intestine
Effect of the Central Nervous System on Mucosal Growth and Apoptosis in the Small Intestine
复制标题
中枢神经系统对小肠粘膜生长和细胞凋亡的影响
作者：
K. Fujimoto;R. Iwakiri;H. Utsumi;M. Kojima;Sadatoshi Ishibashi;Bin Wu;Hiroyuki Sakata;T. Noda
最近我们的研究表明，中枢神经系统部分调节大鼠小肠粘膜细胞的生长和凋亡。鸟氨酸脱羧酶（ODC）是多胺合成的关键酶，对肠粘膜的生长发育起重要作用。我们已经证明，在黑暗期之前，十二指肠中ODC活性的增加被迷走神经干切断术消除，并且2-脱氧-D-葡萄糖注入第三脑室激活小肠中的ODC活性。通过调节细胞增殖和细胞死亡来平衡上皮内稳态。我们的初步数据表明，肠粘膜细胞凋亡减少腹内侧下丘脑损伤大鼠。这些结果表明，中枢神经系统，除了局部因素，在肠粘膜的粘膜稳态的调节。
Recently our studies have demonstrated that the central nervous system regulates in part mucosal cell growth and apoptosis in the rat small intestine. Ornithine decarboxylase (ODC) activity is a key enzyme for polyamine synthesis which plays an important role for the intestinal mucosal growth. We have demonstrated that the increase of ODC activity in the duodenum just before the dark period is abolished by truncal vagotomy and that the infusion of 2-deoxy-D-glucose into the third cerebroventricle activates ODC activity in the small intestine. Epithelial homeostasis is balanced by regulation of cell proliferation and cell death. Our preliminary data showed that intestinal mucosal apoptosis decreased in the ventromedial-hypothalamus-lesioned rat. These results indicate that the central nervous system, in addition to local factors, is related to regulation of mucosal homeostasis in the intestinal mucosa.
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影响因子：
15.9
作者：
FUJIMOTO, K;IMAMURA, I;TSO, P
通讯作者：
TSO, P
组胺受体在大鼠缺血再灌注后肠道修复中的作用。
影响因子：
29.4
作者：
Tsunada,S;Fujimoto,K;Gotoh,Y;Sakai,T;Kang,M;Sakata,T;Granger,DN;Tso,P
通讯作者：
Tso,P
食物诱导粘膜鸟氨酸脱羧酶的机制。
DOI：
10.1152/ajpgi.1986.251.3.g370
发表时间：
1986
期刊：
The American journal of physiology
影响因子：
--
作者：
Tabata,K;Johnson,LR
通讯作者：
Johnson,LR
2,5-脱水-D-甘露醇抑制糖异生和糖原分解。
DOI：
--
发表时间：
1984
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Hanson,RL;Ho,RS;Wiseberg,JJ;Simpson,R;Younathan,ES;Blair,JB
通讯作者：
Blair,JB