Role of histamine receptors in intestinal repair after ischemia-reperfusion in rats.
Role of histamine receptors in intestinal repair after ischemia-reperfusion in rats.
复制标题
组胺受体在大鼠缺血再灌注后肠道修复中的作用。
DOI：
10.1016/0016-5085(94)90530-4
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发表时间：
1994
期刊：
影响因子：
29.4
通讯作者：
Tso,P
中科院分区：
文献类型：
--
作者：
Tsunada,S;Fujimoto,K;Gotoh,Y;Sakai,T;Kang,M;Sakata,T;Granger,DN;Tso,P
背景/目的：以前，我们发现组胺的产生增加促进缺血-再灌注后受损肠粘膜的愈合。本研究旨在探讨组胺介导的肠黏膜缺血再灌注损伤修复是否涉及H1或H2受体的参与。结果：空肠粘膜鸟氨酸脱羧酶活性在再灌注后6 h即明显升高，至48 h仍保持较高水平。缺血-再灌注诱导的鸟氨酸脱羧酶活性增加减弱（以剂量依赖性方式）的H1受体拮抗剂（扑尔敏马来酸盐），但不是由H2拮抗剂（西咪替丁）。腹腔注射H3受体拮抗剂（硫代哌丁胺）可增加肠系膜淋巴液中组胺的分泌，并刺激小肠鸟氨酸脱羧酶的活性。肠缺血24小时后，肠淋巴液中脂质的转运受到抑制，但在缺血-再灌注48小时后恢复到正常水平。结论：组胺对肠黏膜缺血再灌注损伤的修复作用可能与组胺H1受体的参与和激活有关。
Background/Aims:Previously, we showed that an elevated production of histamine promotes the healing of injured intestinal mucosa after ischemia-reperfusion. The aim of the present study was to determine whether histamine-mediated repair of the intestinal mucosa after ischemia-reperfusion involves the engagement of H1or H2receptors.Methods:The superior mesenteric artery was occluded for 15 minutes followed by reperfusion, and H1- or H2-receptor antagonists were infused intraduodenally. After ischemia-reperfusion, ornithine decar☐ylase activity in the jejunal mucosa and lipid transport to mesenteric lymph were examined.Results:In jejunal mucosa, ornithine decar☐ylase activity markedly increased at 6 hours after reperfusion and remained elevated at 48 hours. The ischemia-reperfusion-induced increase in ornithine decar☐ylase activity was attenuated (in a dose-dependent manner) by an H1-receptor antagonist (chlorpheniramine maleate) but not by an H2antagonist (cimetidine). Intraperitoneal injection of an H3antagonist (thioperamide) increased histamine output in mesenteric lymph and stimulated intestinal ornithine decar☐ylase activity. Transport of dietary lipid into mesenteric lymph was depressed 24 hours after an ischemic insult, yet it returned to the normal level 48 hours after ischemia-reperfusion. The recovery of the lipid transport normally observed at 48 hours after ischemia-reperfusion was attenuated by the H1antagonist.Conclusions:The beneficial effects of histamine on the repair of intestinal mucosa after ischemia-reperfusion results from the engagement and activation of the H1receptor.
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影响因子：
15.9
作者：
FUJIMOTO, K;IMAMURA, I;TSO, P
通讯作者：
TSO, P
应用肿瘤启动子乙酸十四烷酰佛波醇后，小鼠皮肤中组氨酸脱羧酶活性增加。
DOI：
--
发表时间：
1981
期刊：
Biochemical and Biophysical Research Communications - BBRC
影响因子：
--
作者：
Takehiko Watanabe;Y. Taguchi;Kazuyuki Sasaki;Kenichiro Tsuyama;Yukihiko Kitamura
通讯作者：
Yukihiko Kitamura
组胺参与小鼠和大鼠肿瘤的生长：单氟甲基组氨酸的抗肿瘤特性，单氟甲基组氨酸是组氨酸脱羧酶的酶激活的不可逆抑制剂。
影响因子：
11.2
作者：
J. Bartholeyns;M. Bouclier
通讯作者：
M. Bouclier
从大鼠肝脏、小肠或胸导管收集淋巴液的技术。
DOI：
10.5555/uri:pii:0022214348903369
发表时间：
1948
期刊：
The Journal of laboratory and clinical medicine
影响因子：
--
作者：
J. Bollman;J. Cain;J. H. Grindlay
通讯作者：
J. H. Grindlay
兔肠系膜缺血时肠二胺氧化酶和组胺的释放。
影响因子：
29.4
作者：
J. Kusche;Wilfried Lorenz;Carl;H. Richter;Rudolf Hesterberg;A. Schmal;E. Hinterlang;Doris Weber;Christian Ohmann
通讯作者：
Christian Ohmann