Sequence of the DNA-binding protein of a human subgroup E adenovirus (type 4): comparisons with subgroup A (type 12), subgroup B (type 7), and subgroup C (type 5).
Sequence of the DNA-binding protein of a human subgroup E adenovirus (type 4): comparisons with subgroup A (type 12), subgroup B (type 7), and subgroup C (type 5).
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人类 E 亚型腺病毒(4 型)的 DNA 结合蛋白序列:与 A 亚型(12 型)、B 亚型(7 型)和 C 亚型(5 型)的比较。
DOI:
10.1016/0042-6822(85)90055-8
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发表时间:
1985
期刊:
影响因子:
3.7
通讯作者:
Kitchingman,GR
中科院分区:
文献类型:
--
作者:
Kitchingman,GR
The nucleotide sequence of the gene for the single-stranded DNA-binding protein of adenovirus type 4 (Ad4) has been determined. The gene codes for a protein of 512 amino acids. Comparison of the amino acid sequence with those previously determined for Ad5, Ad12, and Adz allowed identification of regions that are conserved between the four serotypes. These include stretches of 9, 9, and 12 amino acids in the carboxy-terminal domain of the protein; these sequences are similar to those identified in the single-stranded DNA-binding proteins of procaryotes as being important for interaction of the protein with single-stranded DNA. A conserved region of four amino acids in the amino-terminal domain is identical in sequence to a region of the SV40 large T antigen that has recently been implicated in the nuclear localization of the protein. Other conserved amino acids that may be important for the three-dimensional structure of the protein have also been identified. The overall homology between the DBPs of the four serotypes is 17.2% in the amino-terminal domain, 47.8% in the carboxy-terminal domain. Two-way comparisons between the DBPs of the four serotypes indicates that the DBP of Ad4 is most closely related to that of Adz.
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DOI:
10.1099/0022-1317-44-1-25
发表时间:
1979
期刊:
The Journal of general virology
影响因子:
--
作者:
J. Sussenbach;M. Kuijk;M. van Maarschalkerweerd
通讯作者:
M. van Maarschalkerweerd
影响因子:
64.8
作者:
KALDERON, D;RICHARDSON, WD;SMITH, AE
通讯作者:
SMITH, AE
影响因子:
64.8
作者:
C. Montell;E. Fisher;M. Caruthers;A. Berk
通讯作者:
A. Berk
影响因子:
3.7
作者:
P. C. Vliet;J. Sussenbach
通讯作者:
J. Sussenbach
影响因子:
5.6
作者:
D. Klessig;L. Chow
通讯作者:
L. Chow