A preliminary study of the neural effects of behavioral therapy for substance use disorders.
A preliminary study of the neural effects of behavioral therapy for substance use disorders.
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DOI：
10.1016/j.drugalcdep.2011.10.002
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发表时间：
2012-05-01
影响因子：
4.2
通讯作者：
Potenza MN
中科院分区：
文献类型：
--
作者：
DeVito EE;Worhunsky PD;Carroll KM;Rounsaville BJ;Kober H;Potenza MN
物质使用障碍（SUD）的行为疗法发挥其作用的机制和治疗的组成部分，最有助于物质使用的结果仍然不清楚。冲动控制和注意力方面的中断被假设为有助于成瘾的发展和维持;此外，这些过程的改变可能是治疗反应的基础。参与一项随机临床试验的个人在治疗前后都参加了fMRI Stroop，该试验评估了计算机辅助认知行为疗法（CBT）对药物滥用的影响。一个非物质使用的对照组在重测条件下执行相同的任务。患者组在治疗后相对于治疗前在包括前扣带回、额下回和中脑的区域中表现出Stroop相关BOLD信号降低，并且在重测后与健康对照相比在丘脑底核和周围区域中显示出更大的降低。行为疗法可能与减少物质使用和对涉及认知控制，冲动，动机和注意力的神经系统的影响有关。
The mechanisms by which behavioral therapies for substance use disorders (SUDs) exert their effects and the components of treatment that contribute most to substance use outcome remain unclear. Disruptions to aspects of impulse control and attention have been hypothesized to contribute to the development and maintenance of addiction; moreover, alterations in these processes may underlie responses to treatment. Individuals participating in a randomized clinical trial evaluating computer-assisted cognitive behavioral therapy (CBT) for substance abuse participated in fMRI Stroop before and after treatment. A non-substance-using comparison group performed the same task under test-retest conditions. The patient group demonstrated decreased Stroop-related BOLD signal in regions including the anterior cingulate, inferior frontal gyrus and midbrain at post-treatment relative to pre-treatment, and displayed a greater decrease in the subthalamic nucleus and surrounding regions compared to healthy controls following test-retest. Behavioral therapies may be associated with reduction in substance use and effects on neural systems involved in cognitive control, impulsivity, motivation and attention.
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DOI：
10.1098/rstb.2008.0106
发表时间：
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影响因子：
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