Aquaporin-4 upregulated expression in glioma tissue is a reaction to glioma-associated edema induced by vascular endothelial growth factor.
Aquaporin-4 upregulated expression in glioma tissue is a reaction to glioma-associated edema induced by vascular endothelial growth factor.
复制标题
神经胶质瘤组织中 Aquaporin-4 表达上调是对血管内皮生长因子诱导的神经胶质瘤相关水肿的反应。
DOI：
10.3892/or.2012.1973
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发表时间：
2012-11
期刊：
影响因子：
4.2
通讯作者：
Lin ZX
中科院分区：
文献类型：
--
作者：
Yang LJ;Wang XF;Zhen SM;Zhang S;Kang D,;Lin ZX
神经胶质瘤相关水肿是神经胶质瘤患者发病率和死亡率的重要因素。血管内皮生长因子（VEGF）和水通道蛋白4（AQP 4）在胶质瘤相关水肿中起重要作用。然而，VEGF对AQP 4表达的影响尚不清楚。在这项研究中，AQP 4的表达测定在培养的胶质瘤细胞表达不同量的VEGF，和AQP 4的表达，血管通透性和水含量测定在胶质瘤异种移植表达不同量的VEGF。在体外表达不同量VEGF的胶质瘤细胞中，没有发现AQP 4表达的差异。然而，AQP 4在胶质瘤组织中的表达随着VEGF、血管通透性和含水量的增加而增加。总之，VEGF不直接影响AQP-4的表达。AQP 4在胶质母细胞瘤细胞中的重新分布是对VEGF诱导的血管源性水肿的反应，目的是促进多余液体的重吸收。AQP 4在胶质瘤中的表达模式为胶质瘤相关水肿中发生的分子变化提供了新的见解，并可能有助于制定未来的治疗策略。
Glioma-associated edema contributes significantly to morbidity and death in patients with glioma. It has been suggested that vascular endothelial growth factor (VEGF) and aquaporin-4 (AQP4) play important roles in glioma-associated edema. However, the effect of VEGF on AQP4 expression is not clear. In this study, AQP4 expression was assayed in cultured glioma cells that express different amounts of VEGF, and AQP4 expression, vessel permeability and water content were assayed in glioma xenografts that express different amounts of VEGF. No difference in AQP4 expression was found between glioma cells expressing different VEGF amounts in vitro. However, AQP4 expression was increased in glioma tissue with increased VEGF, vessel permeability and water content. In conclusion, VEGF does not directly affect AQP-4 expression. The redistribution of AQP4 in glioblastoma cells is a reaction to vasogenic edema induced by VEGF for the purpose of facilitating reabsorption of excess fluid. The pattern of AQP4 expression in glioma provides new insights into the molecular changes occurring in glioma-associated edema and may help plan future therapeutic strategies.
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DOI：
--
发表时间：
2003-02
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
B. Badie;J. Schartner;A. Hagar;S. Prabakaran;Todd R Peebles;Becky Bartley;S. Lapsiwala;D. Resnick;Jessica Vorpahl
通讯作者：
B. Badie;J. Schartner;A. Hagar;S. Prabakaran;Todd R Peebles;Becky Bartley;S. Lapsiwala;D. Resnick;Jessica Vorpahl
影响因子：
82.9
作者：
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通讯作者：
Verkman, AS
DOI：
10.1111/j.1440-1681.2009.05244.x
发表时间：
2010-04
影响因子：
2.9
作者：
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通讯作者：
A. Yool;E. A. Brown;G. Flynn
影响因子：
11
作者：
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通讯作者：
Bell, BA
影响因子：
12.7
作者：
Warth, A;Mittelbronn, M;Wolburg, H
通讯作者：
Wolburg, H