Mechanism of Cerebralcare Granule® for Improving Cognitive Function in Resting-State Brain Functional Networks of Sub-healthy Subjects.
Mechanism of Cerebralcare Granule® for Improving Cognitive Function in Resting-State Brain Functional Networks of Sub-healthy Subjects.
复制标题
健脑颗粒(R)改善亚健康者静息态脑功能网络认知功能的机制
DOI：
10.3389/fnins.2017.00410
复制
发表时间：
2017
影响因子：
4.3
通讯作者：
Xu Y
中科院分区：
文献类型：
--
作者：
Li J;Guo H;Ge L;Cheng L;Wang J;Li H;Zhang K;Xiang J;Chen J;Zhang H;Xu Y
Cerebralcare Granule®（CG）是一种中草药，已被用于改善由缺血或精神障碍引起的认知障碍。CG改善健康状况和认知功能的能力引起了研究人员的注意，但CG改善效果的相关脑回路仍不清楚。本研究采用静息态功能磁共振成像（fMRI）技术探讨CG改善亚健康受试者认知功能的神经生物学机制。30名亚健康参与者被指示服用一包2.5 g的CG，每天三次，持续3个月。采用中国修订韦氏成人智力量表（WAIS-RC）和韦氏记忆量表（WMS）评估患者的临床认知功能，并在基线和干预结束时进行fMRI扫描。采用传统网络度量（CNM）和频繁子图挖掘（FSM）对脑功能网络数据进行分析。另选取21名亚健康者作为认知功能的空白对照组。结果发现，服用CG可提高儿童智商（FIQ）和记忆商（MQ）的总分。与此同时，CG治疗后，CG组额叶、颞叶、枕叶皮层和皮层下脑区的功能性脑网络的拓扑性质发生了改变，包括执行注意网络、显著性网络和感觉运动网络的重要组成部分。FSM结果中涉及的节点与CNM的发现基本一致，节点指标的变化与认知功能的改善相关。这些结果表明，CG可以通过改变脑功能网络来改善亚健康受试者的认知功能。这些结果为进一步研究CG的潜在生理机制奠定了基础。
Cerebralcare Granule® (CG), a Chinese herbal medicine, has been used to ameliorate cognitive impairment induced by ischemia or mental disorders. The ability of CG to improve health status and cognitive function has drawn researchers' attention, but the relevant brain circuits that underlie the ameliorative effects of CG remain unclear. The present study aimed to explore the underlying neurobiological mechanisms of CG in ameliorating cognitive function in sub-healthy subjects using resting-state functional magnetic resonance imaging (fMRI). Thirty sub-healthy participants were instructed to take one 2.5-g package of CG three times a day for 3 months. Clinical cognitive functions were assessed with the Chinese Revised Wechsler Adult Intelligence Scale (WAIS-RC) and Wechsler Memory Scale (WMS), and fMRI scans were performed at baseline and the end of intervention. Functional brain network data were analyzed by conventional network metrics (CNM) and frequent subgraph mining (FSM). Then 21 other sub-healthy participants were enrolled as a blank control group of cognitive functional. We found that administrating CG can improve the full scale of intelligence quotient (FIQ) and Memory Quotient (MQ) scores. At the same time, following CG treatment, in CG group, the topological properties of functional brain networks were altered in various frontal, temporal, occipital cortex regions, and several subcortical brain regions, including essential components of the executive attention network, the salience network, and the sensory-motor network. The nodes involved in the FSM results were largely consistent with the CNM findings, and the changes in nodal metrics correlated with improved cognitive function. These findings indicate that CG can improve sub-healthy subjects' cognitive function through altering brain functional networks. These results provide a foundation for future studies of the potential physiological mechanism of CG.
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DOI：
10.1098/rstb.2005.1634
发表时间：
2005-05-29
影响因子：
6.3
作者：
Beckmann, CF;DeLuca, M;Smith, SM
通讯作者：
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影响因子：
15.9
作者：
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通讯作者：
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影响因子：
6.6
作者：
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通讯作者：
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影响因子：
3.1
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通讯作者：
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DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
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通讯作者：
HOCHBERG, Y