Concurrent infiltration by CD8+ T cells and CD4+ T cells is a favourable prognostic factor in non-small-cell lung carcinoma.
Concurrent infiltration by CD8+ T cells and CD4+ T cells is a favourable prognostic factor in non-small-cell lung carcinoma.
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CD8+ T细胞和CD4+ T细胞的同时浸润是非小细胞肺癌中的一个有利的预后因素。
DOI：
10.1038/sj.bjc.6602934
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发表时间：
2006-01-30
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
本研究旨在探讨非小细胞肺癌(NSCLC)患者肿瘤浸润性T淋巴细胞数量与临床病理特征及临床转归的关系。应用免疫组织化学方法检测109例非小细胞肺癌手术切除患者的组织标本中CD4和CD8的表达。患者根据他们的肿瘤表现出CD8+或CD4+淋巴细胞的“高”或“低”水平被分成两组。CD_8~+T细胞单独浸润率虽无预后意义，但CD_8~+和CD_4~+T细胞高浸润者的生存率显著高于其他两组(LOG-RANK检验，P=0.006)。多因素分析显示高CD_8+和高CD_4~+T细胞浸润率是独立的预后因素(P=0.0092)。总之，CD8+T细胞和CD4+T细胞的高水平的存在是NSCLC患者预后较好的一个重要指标，这些细胞群体之间的合作可能比单独使用这两个群体中的任何一个群体都能产生明显更强大的抗肿瘤反应。
The purpose of this study was to clarify the relationship between the number of tumour-infiltrating T lymphocytes and the clinicopathological features and clinical outcome in patients with non-small-cell lung cancer (NSCLC). Tissue specimens from 109 patients who underwent surgical resection for NSCLC were immunohistochemically analysed for CD4 and CD8 expression. Patients were classified into two groups according to whether their tumours exhibited a ‘high’ or ‘low’ level of CD8+ or CD4+ lymphocyte infiltration. Although the level of infiltration by CD8+ T cells alone had no prognostic significance, the survival rate for patients with both ‘high’ CD8+ and ‘high’ CD4+ T-cell infiltration was significantly higher than that for the other groups (log-rank test, P=0.006). Multivariate analysis indicated that concomitant high CD8+ and high CD4+ T-cell infiltration was an independent favourable prognostic factor (P=0.0092). In conclusion, the presence of high levels of both CD8+ T cells and CD4+ T cells is a significant indicator of a better prognosis for patients with NSCLC, and cooperation between these cell populations may allow a significantly more potent antitumour response than either population alone.
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DOI：
10.1084/jem.188.12.2357
发表时间：
1998-12-21
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Hung K;Hayashi R;Lafond-Walker A;Lowenstein C;Pardoll D;Levitsky H
通讯作者：
Levitsky H
影响因子：
64.8
作者：
Rosenberg, SA
通讯作者：
Rosenberg, SA
影响因子：
56.9
作者：
Hahne, M;Rimoldi, D;Tschopp, J
通讯作者：
Tschopp, J
影响因子：
82.9
作者：
Rosenberg, SA;Yang, JC;White, DE
通讯作者：
White, DE
影响因子：
2.5
作者：
Oshikiri, T;Miyamoto, M;Katoh, H
通讯作者：
Katoh, H