Influence of dark phase restricted high fat feeding on myocardial adaptation in mice.
Influence of dark phase restricted high fat feeding on myocardial adaptation in mice.
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DOI：
10.1016/j.yjmcc.2012.09.010
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发表时间：
2013-02
影响因子：
5
通讯作者：
Young ME
中科院分区：
文献类型：
--
作者：
Tsai JY;Villegas-Montoya C;Boland BB;Blasier Z;Egbejimi O;Gonzalez R;Kueht M;McElfresh TA;Brewer RA;Chandler MP;Bray MS;Young ME
长时间高脂肪喂养与啮齿动物心肌收缩功能障碍有关。然而，流行病学数据并不一定支持富含脂肪的饮食对人类心脏功能不利的观点。当以随意的方式喂食时，实验室的啮齿动物一整天都在吃食物。相比之下，人类通常只在清醒时进食。啮齿动物和人类进食行为之间的差异使我们假设一天中饮食脂质消耗的时间显著影响心肌适应。为了更好地模仿人类的进食行为，小鼠只在12小时的黑暗阶段喂食（对照或高脂肪饮食）（即在光明阶段不提供食物）。我们报告说，与黑暗期限制性对照饮食喂养的小鼠相比，在黑暗期喂食高脂肪饮食的小鼠表现出：1)体重增加和能量平衡基本正常；2)全身以及骨骼肌和心肌的脂肪酸氧化增加（在胰岛素和/或高负荷时）；3)诱导脂肪酸应答基因，包括促进心脏甘油三酯转换的基因；4)无心肌肥厚的证据；5)体外评估心肌收缩功能的持续/改善。这些数据与假设一致，即仅在更活跃/清醒的时期摄入膳食脂肪可以充分适应代谢，从而保持心肌收缩功能。
Prolonged high fat feeding is associated with myocardial contractile dysfunction in rodents. However, epidemiological data do not necessarily support the concept that fat-enriched diets adversely affect cardiac function in humans. When fed in an ad libitum manner, laboratory rodents consume chow throughout the day. In contrast, humans typically consume food only during the awake phase. Discrepancies between rodent and human feeding behaviors led us to hypothesize that the time of day at which dietary lipids are consumed significantly influences myocardial adaptation. In order to better mimic feeding behavior in humans, mice were fed (either a control or high fat diet) only during the 12-hr dark phase (i.e., no food was provided during the light phase). We report that compared to dark phase restricted control diet fed mice, mice fed a high fat diet during the dark phase exhibit: 1) essentially normal body weight gain and energy balance; 2) increased fatty acid oxidation at whole body, as well as skeletal and cardiac muscle (in the presence of insulin and/or at high workloads) levels; 3) induction of fatty acid responsive genes, including genes promoting triglyceride turnover in the heart; 4) no evidence of cardiac hypertrophy; and 5) persistence/improvement of myocardial contractile function, as assessed ex vivo. These data are consistent with the hypothesis that ingestion of dietary fat only during the more active/awake period allows adequate metabolic adaptation, thereby preserving myocardial contractile function.
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影响因子：
29
作者：
Hatori M;Vollmers C;Zarrinpar A;DiTacchio L;Bushong EA;Gill S;Leblanc M;Chaix A;Joens M;Fitzpatrick JA;Ellisman MH;Panda S
通讯作者：
Panda S
影响因子：
7
作者：
Gibson, UEM;Heid, CA;Williams, PM
通讯作者：
Williams, PM
影响因子：
7
作者：
Heid, CA;Stevens, J;Williams, PM
通讯作者：
Williams, PM
影响因子：
56.9
作者：
Turek, FW;Joshu, C;Bass, J
通讯作者：
Bass, J
影响因子：
6.5
作者：
Pan, Xiaoyue;Hussain, M. Mahmood
通讯作者：
Hussain, M. Mahmood