MicroRNA signature and regulatory functions in the endometrium during normal and disease states.
MicroRNA signature and regulatory functions in the endometrium during normal and disease states.
复制标题
DOI：
10.1055/s-0028-1096128
复制
发表时间：
2008-11
影响因子：
2.7
通讯作者：
Chegini N
中科院分区：
文献类型：
--
作者：
Pan Q;Chegini N
在月经周期中，人类子宫内膜经历广泛的周期性形态和生化修饰，为胚胎着床做准备。这些过程受到卵巢类固醇和各种局部表达的基因产物的高度调节，并且涉及炎症反应、凋亡、细胞增殖、血管生成、分化（组织形成）和组织重塑。微小RNA（miRNAs）已经成为基因表达的关键调节因子，并且它们的改变和/或异常表达已经与包括肿瘤发生在内的各种病症的建立和进展相关。这篇综述强调了正常和病理条件下，如子宫内膜异位症，功能失调性子宫出血和子宫内膜癌的miRNAs表达及其潜在的调节功能。鉴于miRNAs对基因表达稳定性的关键调控功能，了解子宫内膜miRNAs如何调控的潜在机制并识别其特异性靶基因及其功能可能会导致通过调控与此类生殖疾病相关的特异性靶基因来制定预防和治疗策略。
During the menstrual cycle, human endometrium undergoes extensive cyclic morphologic and biochemical modifications in preparation for embryo implantation. These processes are highly regulated by ovarian steroids and various locally expressed gene products and involve inflammatory reaction, apoptosis, cell proliferation, angiogenesis, differentiation (tissue formation), and tissue remodeling. MicroRNAs (miRNAs) have emerged as key regulators of gene expression, and their altered and/or aberrant expression has been associated with establishment and progression of various disorders, including tumorigenesis. This review highlights the endometrial expression of miRNAs and their potential regulatory functions under normal and pathologic conditions such as endometriosis, dysfunctional uterine bleeding, and endometrial cancer. Given the key regulatory function of miRNAs on gene expression stability, understanding the underlying mechanisms of how endometrial miRNAs are regulated and identifying their specific target genes and their functions might lead to the development of preventive and therapeutic strategies by regulating specific target genes associated with such reproductive disorders.
登录
查看更多内容
影响因子：
4.7
作者：
Boren, Todd;Xiong, Yin;Lancaster, Johnathan M.
通讯作者：
Lancaster, Johnathan M.
影响因子：
6.1
作者：
Chegini, N.;Luo, X.;Archer, D. F.
通讯作者：
Archer, D. F.
影响因子：
3.4
作者：
Chegini, N;Ma, CF;Ripps, BA
通讯作者：
Ripps, BA
影响因子：
20.3
作者：
Chen, Yun;Gorski, David H.
通讯作者：
Gorski, David H.
影响因子：
4.3
作者：
Carleton, Michael;Cleary, Michele A.;Linsley, Peter S.
通讯作者：
Linsley, Peter S.