Thyroid hormone regulation by stress and behavioral differences in adult male rats.
Thyroid hormone regulation by stress and behavioral differences in adult male rats.
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成年雄性大鼠的压力和行为差异调节甲状腺激素。
DOI：
10.1016/j.yhbeh.2011.06.003
复制
发表时间：
2011-08
影响因子：
3.5
通讯作者：
Tylee, Daniel
中科院分区：
文献类型：
--
作者：
Helmreich, Dana L.;Tylee, Daniel
甲状腺激素是生长、发育和正常身体功能的重要调节因子，其释放由下丘脑-垂体-甲状腺（HPT）轴协调。虽然HPT轴已被确定为急性应激反应的神经内分泌系统，但对其应激调节机制的了解相对较少。本研究探讨了急性应激诱导的外周激素水平[三碘甲状腺原氨酸（T3），甲状腺素（T4），促甲状腺激素（TSH），反三碘甲状腺原氨酸（rT 3）]和中央的HPT轴调节因子[促甲状腺激素释放激素（TRH），生长抑素（SST），II型脱碘酶（D2）]的mRNA水平的变化，在一个不可避免的尾部休克，啮齿动物模型的压力。此外，我们还研究了在旷场试验中自发探索行为的个体差异是否可以预测TH的基础水平或对压力影响的敏感性差异。与对照组相比，应激条件与外周T3、T4和TSH的降低有关，但与rT 3无关。TRH或SST mRNA水平没有观察到变化，但有一种趋势表明应激相关的D2 mRNA增加。我们还发现，动物的探索行为在一个不熟悉的开放领域竞技场正相关的外周甲状腺激素水平和预测的压力引起的变化的幅度。总之，我们发现了提示性的证据表明，在中央驱动HPT轴的应激诱导减少，但其应激调节的中枢机制仍有待阐明。此外，我们发现动物探索行为的个体差异与外周TH水平相关。
Thyroid hormones are essential regulators of growth, development and normal bodily function and their release is coordinated by the hypothalamic-pituitary-thyroid (HPT) axis. While the HPT axis has been established as an acutely stress-responsive neuroendocrine system, relatively little is known about the mechanisms of its stress-regulation. The present study examined acute stress-induced changes in peripheral hormone levels [triiodothyronine (T3); thyroxine (T4), thyroid-stimulating hormone (TSH), reverse triiodothyronine (rT3)] and central mRNA levels of regulators of the HPT axis [thyrotropin-releasing hormone (TRH), somatostatin (SST), type II deiodinase (D2)] in response to an inescapable tail-shock, a rodent model of stress. Additionally, we examined whether individual differences in spontaneous exploratory behavior in an open field test predicted basal levels of TH or differential susceptibility to the effects of stress. The stress condition was associated with decreases in peripheral T3, T4 and TSH, but not rT3, when compared with controls. No changes were observed in TRH or SST mRNA levels, but there was a trend suggesting stress-related increases in D2 mRNA. We also found that an animal's exploratory behavior in an unfamiliar open field arena was positively related to peripheral thyroid hormone levels and predicted the magnitude of stress-induced changes. In conclusion, we found suggestive evidence for stress-induced decrease in central drive HPT axis, but the central mechanisms of its stress-regulation remain to be elucidated. Additionally, we found that individual differences in animals' exploratory behavior were correlated with peripheral TH levels.
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影响因子：
2
作者：
Gönen, MS;Kisakol, G;Kaya, A
通讯作者：
Kaya, A
影响因子：
4.1
作者：
Cizza, G;Brady, LS;Chrousos, GP
通讯作者：
Chrousos, GP
DOI：
10.1016/j.beem.2009.08.003
发表时间：
2009-12
期刊：
Best practice & research. Clinical endocrinology & metabolism
影响因子：
--
作者：
Haugen BR
通讯作者：
Haugen BR
DOI：
10.1073/pnas.0805355106
发表时间：
2009-04-07
影响因子：
11.1
作者：
Klieverik, Lars P.;Janssen, Sarah F.;Kalsbeek, Andries
通讯作者：
Kalsbeek, Andries
影响因子：
4.8
作者：
Kalsbeek, A;Fliers, E;Buijs, RM
通讯作者：
Buijs, RM