Bone quality changes associated with aging and disease: a review.
Bone quality changes associated with aging and disease: a review.
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骨质变化与衰老和疾病有关：评论。
DOI：
10.1111/nyas.13572
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发表时间：
2017-12
影响因子：
5.2
通讯作者：
Imbert L
中科院分区：
文献类型：
--
作者：
Boskey AL;Imbert L
骨质量包括骨的所有特性，除了密度之外，还有助于其抵抗骨折。在这篇综述中，我们考虑了结构，孔隙率和组成，包括胶原蛋白结构，矿物质组成和晶体大小的变化。已知这些因素都随组织和动物年龄以及健康状况而变化。骨形态和微裂纹的存在也有助于骨质量，将不在本综述中讨论。胶原交联度、结晶度和碳酸盐含量与力学性能的相关性与矿物质含量进行了对比。在人类和啮齿动物的年龄依赖性变化进行了讨论，在使用啮齿动物疾病模型。在人类和动物模型中的实例是骨质疏松症、骨软化症、骨生成异常和骨硬化症。这些情况中的每一种，沿着老化，由于不同的原因与骨折风险增加相关。
Bone quality encompasses all the characteristics of bone that, in addition to density, contribute to its resistance to fracture. In this review, we consider changes in architecture, porosity and composition, including collagen structure, mineral composition and crystal size. These factors all are known to vary with tissue and animal ages, and health status. Bone morphology and presence of micro-cracks which also contribute to bone quality, will not be discussed in this review. Correlations with mechanical performance for collagen cross-linking, crystallinity and carbonate content are contrasted with mineral content. Age dependent changes in humans and rodents are discussed in terms of using rodent models of disease. Examples are osteoporosis, osteomalacia, osteogenesis imperfecta, and osteopetrosis, in both humans and animal models. Each of these conditions, along with aging, are associated with increased fracture risk for distinct reasons.
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DOI：
10.1002/jbmr.2759
发表时间：
2016-05
期刊：
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
影响因子：
--
作者：
Boskey AL;Donnelly E;Boskey E;Spevak L;Ma Y;Zhang W;Lappe J;Recker RR
通讯作者：
Recker RR
影响因子：
4.1
作者：
Bae, Won C.;Patil, Shantanu;Biswas, Reni;Li, Shihong;Chang, Eric Y.;Statum, Sheronda;D'Lima, Darryl D.;Chung, Christine B.;Du, Jiang
通讯作者：
Du, Jiang
影响因子：
2.9
作者：
Bart, Zachary R.;Hammond, Max A.;Wallace, Joseph M.
通讯作者：
Wallace, Joseph M.
影响因子：
4.2
作者：
Camacho, NP;Carroll, P;Raggio, CL
通讯作者：
Raggio, CL
影响因子：
3.6
作者：
Bargman, Renee;Poshann, Ram;Pleshko, Nancy
通讯作者：
Pleshko, Nancy