Magnetic resonance imaging assessed cortical porosity is highly correlated with μCT porosity.
Magnetic resonance imaging assessed cortical porosity is highly correlated with μCT porosity.
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DOI：
10.1016/j.bone.2014.06.004
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发表时间：
2014-09
期刊：
影响因子：
4.1
通讯作者：
Du, Jiang
中科院分区：
文献类型：
--
作者：
Bae, Won C.;Patil, Shantanu;Biswas, Reni;Li, Shihong;Chang, Eric Y.;Statum, Sheronda;D'Lima, Darryl D.;Chung, Christine B.;Du, Jiang
皮质骨通常被认为是常规临床磁共振成像（MRI）脉冲序列的“MR不可见”。然而，最近的研究表明，皮质骨的微观孔隙中的自由水具有短T2* 但相对长的T2，并且可以用常规临床自旋回波（SE）或快速自旋回波（FSE）序列检测到。在这项研究中，我们描述了使用传统的二维（2D）FSE序列来评估皮质骨的微观结构，并使用临床3 T扫描仪测量皮质孔隙率。使用MRI和微型计算机断层扫描（μCT）（下采样至相同的空间分辨率）研究了12个尸体人皮质骨样本。初步结果表明，FSE测定的孔隙度与μCT孔隙度高度相关（R2 = 0.83; P < 0.0001）。Bland Altman分析表明FSE和μCT之间具有良好的一致性，一致性的严格限制约为3%。FSE数据也存在-2%的小偏倚，这表明FSE方法略微低估了μCT孔隙度。结果表明，皮质孔隙度可以直接评估使用传统的临床FSE序列。该方法的临床可行性也在6名健康志愿者身上得到了证实，使用2D FSE序列以及最小回波时间（TE）为8 μs的2D超短回波时间（UTE）序列，可提供体内皮质骨的高对比度成像。
Cortical bone is typically regarded as “MR invisible” with conventional clinical magnetic resonance imaging (MRI) pulse sequences. However, recent studies have demonstrated that free water in the microscopic pores of cortical bone has a short T2* but a relatively long T2, and may be detectable with conventional clinical spin echo (SE) or fast spin echo (FSE) sequences. In this study we describe the use of a conventional two-dimensional (2D) FSE sequence to assess cortical bone microstructure and measure cortical porosity using a clinical 3T scanner. Twelve cadaveric human cortical bone samples were studied with MRI and micro computed tomography (μCT) (downsampled to the same spatial resolution). Preliminary results show that FSE-determined porosity is highly correlated (R2 = 0.83; P < 0.0001) with μCT porosity. Bland Altman analysis suggested a good agreement between FSE and μCT with tight limit of agreement at around 3%. There is also a small bias of -2% for the FSE data, which suggested that the FSE approach slightly underestimated μCT porosity. The results demonstrate that cortical porosity can be directly assessed using conventional clinical FSE sequences. The clinical feasibility of this approach was also demonstrated on six healthy volunteers using 2D FSE sequences as well as 2D ultrashort echo time (UTE) sequences with a minimal echo time (TE) of 8 μs, which provide high contrast imaging of cortical bone in vivo.
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影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
影响因子：
4.1
作者：
Biswas, Reni;Bae, Won;Diaz, Eric;Masuda, Koichi;Chung, Christine B.;Bydder, Graeme M.;Du, Jiang
通讯作者：
Du, Jiang
DOI：
10.2106/00004623-195840020-00015
发表时间：
1958-01-01
影响因子：
5.3
作者：
COHEN, J;HARRIS, WH
通讯作者：
HARRIS, WH
影响因子：
2.9
作者：
Diaz, Eric;Chung, Christine B.;Du, Jiang
通讯作者：
Du, Jiang
影响因子：
3.3
作者：
Du, Jiang;Diaz, Eric;Bydder, Graeme M.
通讯作者：
Bydder, Graeme M.