The Mammary Microenvironment in Mastitis in Humans, Dairy Ruminants, Rabbits and Rodents: A One Health Focus.
The Mammary Microenvironment in Mastitis in Humans, Dairy Ruminants, Rabbits and Rodents: A One Health Focus.
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DOI：
10.1007/s10911-018-9395-1
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发表时间：
2018-06
影响因子：
2.5
通讯作者：
Watson CJ
中科院分区：
文献类型：
--
作者：
Hughes K;Watson CJ
“同一个健康”概念促进对人类、动物和环境健康问题的综合评估，以加快造福所有物种的进展。认识到乳腺炎的多物种影响，作为一种痛苦的条件与福利的影响，使我们建议，乳腺炎是一个理想的目标，一个健康的方法。在这篇综述中，我们将评估乳腺微环境在人类、反刍动物和兔子乳腺炎中的作用，在适当的情况下也会利用实验室动物模型进行研究。我们将检查亚临床乳腺炎、临床哺乳期乳腺炎和复发相关的乳腺炎，或干燥期乳腺炎，强调重要的解剖学和免疫学物种差异。我们将综合在不同物种中获得的知识，比较和对比疾病的表现。亚临床乳腺炎（SCM）的特征是Na/K比值升高，乳中IL-8浓度升高。影响母乳喂养母亲的SCM可能导致婴儿粘膜免疫系统发育的调节，而反刍动物的产奶量可能随之显著减少。在临床乳腺炎的情况下，我们将重点关注由金黄色葡萄球菌和大肠杆菌引起的乳腺炎。了解与对复相关的乳腺炎的发病机制需要表征对复过程中发生的结构和分子变化，我们将回顾跨物种的这些变化。我们推测，牛奶的积累可能是感染的病灶，而“伤口愈合表型”的复旧可能使组织容易受到细菌感染。我们将讨论同时怀孕的影响和“平行怀孕和复旧签名”在牛乳房复旧。
The One Health concept promotes integrated evaluation of human, animal, and environmental health questions to expedite advances benefiting all species. A recognition of the multi-species impact of mastitis as a painful condition with welfare implications leads us to suggest that mastitis is an ideal target for a One Health approach. In this review, we will evaluate the role of the mammary microenvironment in mastitis in humans, ruminants and rabbits, where appropriate also drawing on studies utilising laboratory animal models. We will examine subclinical mastitis, clinical lactational mastitis, and involution-associated, or dry period, mastitis, highlighting important anatomical and immunological species differences. We will synthesise knowledge gained across different species, comparing and contrasting disease presentation. Subclinical mastitis (SCM) is characterised by elevated Na/K ratio, and increased milk IL-8 concentrations. SCM affecting the breastfeeding mother may result in modulation of infant mucosal immune system development, whilst in ruminants notable milk production losses may ensue. In the case of clinical lactational mastitis, we will focus on mastitis caused by Staphylococcus aureus and Escherichia coli. Understanding of the pathogenesis of involution-associated mastitis requires characterization of the structural and molecular changes occurring during involution and we will review these changes across species. We speculate that milk accumulation may act as a nidus for infection, and that the involution ‘wound healing phenotype’ may render the tissue susceptible to bacterial infection. We will discuss the impact of concurrent pregnancy and a ‘parallel pregnancy and involution signature’ during bovine mammary involution.
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DOI：
10.1155/2014/659801
发表时间：
2014
期刊：
Journal of veterinary medicine
影响因子：
--
作者：
Ezzat Alnakip M;Quintela-Baluja M;Böhme K;Fernández-No I;Caamaño-Antelo S;Calo-Mata P;Barros-Velázquez J
通讯作者：
Barros-Velázquez J
影响因子：
10.5
作者：
Chapman, RS;Lourenco, PC;Watson, CJ
通讯作者：
Watson, CJ
用脂多糖或脂肪酸的预处理可防止小鼠葡萄球菌乳腺乳腺感染。
影响因子：
7.3
作者：
Breyne K;Steenbrugge J;Demeyere K;Vanden Berghe T;Meyer E
通讯作者：
Meyer E
影响因子：
7.4
作者：
Dolan, S;Field, LC;Nolan, AM
通讯作者：
Nolan, AM
影响因子：
2.5
作者：
Contreras, G. Andres;Miguel Rodriguez, Juan
通讯作者：
Miguel Rodriguez, Juan