Multiple Roots of Fruiting Body Formation in Amoebozoa.
Multiple Roots of Fruiting Body Formation in Amoebozoa.
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DOI：
10.1093/gbe/evy011
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发表时间：
2018-02-01
影响因子：
3.3
通讯作者：
Glöckner G
中科院分区：
文献类型：
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作者：
Hillmann F;Forbes G;Novohradská S;Ferling I;Riege K;Groth M;Westermann M;Marz M;Spaller T;Winckler T;Schaap P;Glöckner G
多细胞的建立代表了真核生物进化的一个重大转变。阿米巴虫的一个亚群，双基骨类动物，已经进化出一个相对简单的聚集多细胞阶段，产生一个由茎支撑的子实体。原柱状阿米巴原虫分布在整个阿米巴原虫树中，其不同之处在于只产生一个或几个单柄孢子。因此，原骨类动物和双骨类动物发育周期的一个明显区别似乎是多细胞的建立。为了将孢子发育从多细胞相互作用中分离出来，我们比较了一种原柱菌（Protostelium aurantium var. fungivorum）与阿米巴原虫的群居和独居成员的基因组和转录组。在子实体形成过程中，有近4000个基因被上调，这些基因对应于分化过程所需的特定途径。通过与dictyostliids发育相关基因的比较，我们发现在棘阿米巴（Acanthamoeba castellanii）中保存了约500个基因，但其中大多数基因也存在于未记录子实体的棘阿米巴（Acanthamoeba castellanii）中。此外，这些基因的表达调控在金黄色葡萄球菌和盘状盘齿钢柱之间存在差异。在变形虫中，向子实体分化是常见的，但我们目前的基因组分析表明，原甾体和双甾体采用不同的途径来实现这一目标。最值得注意的是，介导环境感知和信号处理的基因在物种之间具有巨大的多样性和多样性。这可能反映了单细胞阶段对不同环境条件的巨大适应性。我们推测，这种信号库提供了足够的构建模块，以适应早期多细胞形式中相对简单的细胞-细胞通信需求。
Establishment of multicellularity represents a major transition in eukaryote evolution. A subgroup of Amoebozoa, the dictyosteliids, has evolved a relatively simple aggregative multicellular stage resulting in a fruiting body supported by a stalk. Protosteloid amoeba, which are scattered throughout the amoebozoan tree, differ by producing only one or few single stalked spores. Thus, one obvious difference in the developmental cycle of protosteliids and dictyosteliids seems to be the establishment of multicellularity. To separate spore development from multicellular interactions, we compared the genome and transcriptome of a Protostelium species (Protostelium aurantium var. fungivorum) with those of social and solitary members of the Amoebozoa. During fruiting body formation nearly 4,000 genes, corresponding to specific pathways required for differentiation processes, are upregulated. A comparison with genes involved in the development of dictyosteliids revealed conservation of >500 genes, but most of them are also present in Acanthamoeba castellanii for which fruiting bodies have not been documented. Moreover, expression regulation of those genes differs between P. aurantium and Dictyostelium discoideum. Within Amoebozoa differentiation to fruiting bodies is common, but our current genome analysis suggests that protosteliids and dictyosteliids used different routes to achieve this. Most remarkable is both the large repertoire and diversity between species in genes that mediate environmental sensing and signal processing. This likely reflects an immense adaptability of the single cell stage to varying environmental conditions. We surmise that this signaling repertoire provided sufficient building blocks to accommodate the relatively simple demands for cell–cell communication in the early multicellular forms.
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影响因子：
4.6
作者：
Kawabe Y;Schilde C;Du Q;Schaap P
通讯作者：
Schaap P
影响因子：
10.7
作者：
Kang S;Tice AK;Spiegel FW;Silberman JD;Pánek T;Cepicka I;Kostka M;Kosakyan A;Alcântara DMC;Roger AJ;Shadwick LL;Smirnov A;Kudryavtsev A;Lahr DJG;Brown MW
通讯作者：
Brown MW
DOI：
10.1111/j.1095-8312.2007.00864.x
发表时间：
2007-12-01
影响因子：
1.9
作者：
Hess, Pablo N.;De Moraes Russo, Claudia A.
通讯作者：
De Moraes Russo, Claudia A.
影响因子：
3.4
作者：
Hedges, SB;Blair, JE;Shoe, JL
通讯作者：
Shoe, JL
DOI：
10.1007/978-94-017-9642-2_17
发表时间：
2015-01-01
期刊：
EVOLUTIONARY TRANSITIONS TO MULTICELLULAR LIFE: PRINCIPLES AND MECHANISMS
影响因子：
--
作者：
Gloeckner, Gernot
通讯作者：
Gloeckner, Gernot