No evidence for a trade-off between reproductive investment and immunity in a rodent.
No evidence for a trade-off between reproductive investment and immunity in a rodent.
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DOI：
10.1371/journal.pone.0037182
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Wang DH
中科院分区：
文献类型：
--
作者：
Xu YC;Yang DB;Wang DH
生命史理论认为，在生殖和免疫等相互竞争的功能之间存在权衡。尽管对鸟类的研究很充分，但对小型哺乳动物繁殖和免疫之间权衡的研究很少。在这里，我们研究了免疫力降低是否是哺乳期勃兰特田鼠（Lasiopodomys brandtii）繁殖努力的结果。具体来说，我们测试了哺乳对免疫功能的影响（实验一）。结果表明，哺乳期田鼠（6≤产仔数≤8）的摄食量和静息代谢率（RMR）高于非生殖期田鼠。与我们的预期相反，泌乳田鼠的血清总免疫球蛋白G （IgG）和抗锁眼帽白血青素（KLH） IgG水平也较高，而植物血凝素（PHA）反应和抗KLH免疫球蛋白M （IgM）没有变化，表明免疫功能得到改善而不是降低。为了进一步检验生殖投入差异对免疫的影响，我们比较了自然大产仔数（n≥8）和小产仔数（n≤6）（实验二）以及人为大产仔数（11-13）和小产仔数（2-3）（实验三）的应答。在哺乳期高峰期，尽管在繁殖投入方面（产仔数、产仔质量、RMR和食物摄取量较大）存在显著差异，但在两个实验中，产仔数大的田鼠和产仔数小的田鼠之间获得性免疫（PHA应答、抗klh IgG和抗klh IgM）均无显著差异。自然产仔数大的田鼠总IgG高于自然产仔数小的田鼠，而产仔数大的田鼠总IgG低于自然产仔数小的田鼠。我们的研究结果表明，勃兰特田鼠的免疫功能不会被抑制以补偿哺乳期间的高能量需求，与鸟类的情况相反，不太可能是调解繁殖与生存之间权衡的重要方面。
Life history theory assumes there are trade-offs between competing functions such as reproduction and immunity. Although well studied in birds, studies of the trade-offs between reproduction and immunity in small mammals are scarce. Here we examined whether reduced immunity is a consequence of reproductive effort in lactating Brandt's voles (Lasiopodomys brandtii). Specifically, we tested the effects of lactation on immune function (Experiment I). The results showed that food intake and resting metabolic rate (RMR) were higher in lactating voles (6≤ litter size ≤8) than that in non-reproductive voles. Contrary to our expectation, lactating voles also had higher levels of serum total Immunoglobulin G (IgG) and anti-keyhole limpet hemocyanin (KLH) IgG and no change in phytohemagglutinin (PHA) response and anti-KLH Immunoglobulin M (IgM) compared with non-reproductive voles, suggesting improved rather than reduced immune function. To further test the effect of differences in reproductive investment on immunity, we compared the responses between natural large (n≥8) and small litter size (n≤6) (Experiment II) and manipulated large (11–13) and small litter size (2–3) (Experiment III). During peak lactation, acquired immunity (PHA response, anti-KLH IgG and anti-KLH IgM) was not significantly different between voles raising large or small litters in both experiments, despite the measured difference in reproductive investment (greater litter size, litter mass, RMR and food intake in the voles raising larger litters). Total IgG was higher in voles with natural large litter size than those with natural small litter size, but decreased in the enlarged litter size group compared with control and reduced group. Our results showed that immune function is not suppressed to compensate the high energy demands during lactation in Brandt's voles and contrasting the situation in birds, is unlikely to be an important aspect mediating the trade-off between reproduction and survival.
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发表时间：
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影响因子：
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作者：
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发表时间：
1992-09-01
期刊：
PHYSIOLOGICAL ZOOLOGY
影响因子：
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作者：
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通讯作者：
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10.1098/rspb.2004.2678
发表时间：
2004-05-07
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