Substituted dithiazole piperazine benzamides as novel amyloid beta peptide reducing agents.
Substituted dithiazole piperazine benzamides as novel amyloid beta peptide reducing agents.
复制标题
取代的二硫唑哌嗪苯甲酰胺作为新型淀粉样β肽还原剂。
DOI：
10.1016/j.bmcl.2014.08.022
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发表时间：
2014-09-15
影响因子：
2.7
通讯作者：
Nefzi, Adel
中科院分区：
文献类型：
--
作者：
Wang, Hongjie;Wang, Ruizhi;Lakshmana, Madepalli K.;Nefzi, Adel
Alzheimer’s disease is a persistent neurodegenerative disorder of elderly characterized clinically by irreversible loss of memory due to accumulation of amyloid beta peptides within the amyloid plaques. We report the parallel synthesis and screening results of diverse substituted di-thiazole piperazine benzamides. A new compound TPI-1917-49 was identified as a promising amyloid reducing agent by lowering the levels of Aβ at least in two cell types and in vivo.
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影响因子：
3.5
作者：
Shiradkar, Mahendra Ramesh;Akula, Kalyan Chakravarthy;Kaur, Ranjit
通讯作者：
Kaur, Ranjit
影响因子：
8.3
作者：
Smith EE;Greenberg SM
通讯作者：
Greenberg SM
影响因子：
3.4
作者：
Gakhar-Koppole, Nidhi;Hundeshagen, Phillip;Ciccolini, Francesca
通讯作者：
Ciccolini, Francesca
影响因子：
1.8
作者：
Nefzi, Adel;Arutyunyan, Sergey
通讯作者：
Arutyunyan, Sergey
影响因子：
4.8
作者：
Lakshmana, Madepalli K.;Chung, John Y.;Kang, David E.
通讯作者：
Kang, David E.