N6-methyladenine modification in noncoding RNAs and its function in cancer.
N6-methyladenine modification in noncoding RNAs and its function in cancer.
复制标题
非编码RNA中的N6-甲基腺嘌呤修饰及其在癌症中的作用
DOI：
10.1186/s40364-020-00244-x
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发表时间：
2020-11-10
影响因子：
11.1
通讯作者：
Ma D
中科院分区：
文献类型：
--
作者：
Yang X;Hu X;Liu J;Wang R;Zhang C;Han F;Chen Y;Ma D
Non-coding RNAs are the main component of the extensive transcription results of the mammalian genome. They are not transcribed into proteins but play critical roles in regulating multiple biological processes and affecting cancer progression. m6A modification is one of the most abundant internal RNA modification of mammalian cells, and it involves almost all aspects of RNA metabolism. Recent research revealed tight correlations between m6A modification and ncRNAs and indicated the interaction between m6A and ncRNAs act a pivotal part in the development of cancer. The correlation between m6A modification and ncRNAs provides a new perspective for exploring the potential regulatory mechanism of tumor gene expression, and suggest that m6A modification and ncRNAs may be important prognostic markers and therapeutic targets for multiple cancers. In this review, we summarize the potential regulatory mechanisms between m6A methylation and ncRNAs, highlighting how their relationship affects biological functions in cancer.
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