The Discovery of Ribosome Heterogeneity and Its Implications for Gene Regulation and Organismal Life.
The Discovery of Ribosome Heterogeneity and Its Implications for Gene Regulation and Organismal Life.
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DOI：
10.1016/j.molcel.2018.07.018
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发表时间：
2018-08-02
期刊：
影响因子：
16
通讯作者：
Barna M
中科院分区：
文献类型：
--
作者：
Genuth NR;Barna M
核糖体最近已经从一个被动的、不分青红皂白的机器转变为一个更动态的大分子复合物，在细胞中具有特殊的作用。在这里，我们讨论从核糖体本身的发现到这个古老的机器如何在基因表达的中心教条中获得更多的监管参与者的新发现的里程碑。第一个在RNA和蛋白质水平上直接改变核糖体组成的例子，加上对单个核糖体成分在特定mrna翻译中所起作用的认识的增加，正在开辟一个以核糖体介导的基因调控控制为中心的新研究领域。在这一观点中，我们讨论了我们目前对核糖体异质性的已知功能的理解，包括个体转录物的特化翻译及其对重要基因调控网络的调控和表达的影响。此外，我们建议接下来的关键步骤是确定核糖体异质性和特化的程度，以及它在亚细胞空间、不同细胞类型和多细胞有机体发育过程中对蛋白质组调节的重要性。核糖体，虽然以前被认为是一个同质和不分青红皂白的机器，最近被认为在基因表达的调节中起着核心作用。从这个角度来看，我们讨论了核糖体的异质性，其中不同组成的核糖体可能存在于细胞内和组织中，以及特定类别的核糖体在翻译控制中的功能。
The ribosome has recently transitioned from being viewed as a passive, indiscriminate machine to a more dynamic macromolecular complex with specialized roles in the cell. Here, we discuss the historical milestones from the discovery of the ribosome itself to how this ancient machinery has gained newfound appreciation as a more regulatory participant in the central dogma of gene expression. The first emerging examples of direct changes in ribosome composition at the RNA and protein level, coupled with an increased awareness of the role individual ribosomal components play in the translation of specific mRNAs, is opening a new field of study centered on ribosome-mediated control of gene regulation. In this Perspective, we discuss our current understanding of the known functions for ribosome heterogeneity including specialized translation of individual transcripts and its implications for the regulation and expression of important gene regulatory networks. In addition, we suggest what the crucial next steps are to ascertain the extent of ribosome heterogeneity and specialization and its importance for regulation of the proteome within subcellular space, across different cell types, and during multi-cellular organismal development. The ribosome, while previously viewed as a homogenous and indiscriminate machine, has recently been recognized to play a central role in the regulation of gene expression. In this Perspective, we discuss ribosome heterogeneity, where ribosomes of distinct compositions may be present both within cells and across tissues, and the functions of specific classes of ribosomes in translational control.
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DOI：
10.1261/rna.043653.113
发表时间：
2014-07
期刊：
RNA (New York, N.Y.)
影响因子：
--
作者：
Gupta V;Warner JR
通讯作者：
Warner JR
影响因子：
64.8
作者：
BRENNER, S;MESELSON, M;JACOB, F
通讯作者：
JACOB, F
影响因子：
64.5
作者：
ARNHEIM, N;SOUTHERN, EM
通讯作者：
SOUTHERN, EM
影响因子：
16.6
作者：
Fujii K;Shi Z;Zhulyn O;Denans N;Barna M
通讯作者：
Barna M
影响因子：
16
作者：
Higgins, Renee;Gendron, Joshua M.;Rising, Lisa;Mak, Raymond;Webb, Kristofor;Kaiser, Stephen E.;Zuzow, Nathan;Riviere, Paul;Yang, Bing;Fenech, Emma;Tang, Xin;Lindsay, Scott A.;Christianson, John C.;Hampton, Randolph Y.;Wasserman, Steven A.;Bennett, Eric J.
通讯作者：
Bennett, Eric J.