Regulation of Immune Responses by Nonhematopoietic Cells in Asthma.
Regulation of Immune Responses by Nonhematopoietic Cells in Asthma.
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DOI：
10.4049/jimmunol.2000885
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发表时间：
2021-01-15
期刊：
影响因子：
--
通讯作者：
Cook DN
中科院分区：
文献类型：
--
作者：
Royer DJ;Cook DN
非造血细胞正在成为许多疾病的重要贡献者，包括过敏性哮喘。最近的进展使人们更深入地了解这些细胞如何与传统免疫细胞相互作用，从而调节它们在体内平衡和疾病中的活动。除了它们在气体交换和屏障功能中的既定作用之外，肺上皮细胞还表达可以由各种吸入的环境因子触发的先天传感器的武器，从而导致促炎分子的产生。细胞谱系追踪和单细胞RNA测序的进展扩大了我们对罕见但在免疫学上重要的非造血细胞群体的认识。与这些进展平行的是，新的反向遗传学方法正在揭示不同肺驻留非造血细胞群体中的个体基因如何促进哮喘的发生和维持。这些知识已经揭示了新的途径，可以选择性地靶向治疗不同形式的哮喘。
Nonhematopoietic cells are emerging as important contributors to many diseases, including allergic asthma. Recent advances have led to a deeper understanding of how these cells interact with traditional immune cells, thereby modulating their activities in both homeostasis and disease. In addition to their well-established roles in gas exchange and barrier function, lung epithelial cells express an armament of innate sensors that can be triggered by various inhaled environmental agents, leading to the production of proinflammatory molecules. Advances in cell lineage tracing and single cell RNA-sequencing have expanded our knowledge of rare, but immunologically important nonhematopoietic cell populations. In parallel with these advances, novel reverse genetic approaches are revealing how individual genes in different lung-resident nonhematopoietic cell populations contribute to the initiation and maintenance of asthma. This knowledge is already revealing new pathways that can be selectively targeted to treat distinct forms of asthma.
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影响因子：
4.3
作者：
Barczyk, A;Pierzchala, W;Sozañska, E
通讯作者：
Sozañska, E
影响因子：
5.6
作者：
Gao ZG;Jacobson KA
通讯作者：
Jacobson KA
DOI：
10.1513/pats.200803-025hr
发表时间：
2008-09-15
期刊：
Proceedings of the American Thoracic Society
影响因子：
--
作者：
Franks, Teri J;Colby, Thomas V;Williams, Mary C
通讯作者：
Williams, Mary C
影响因子：
4.4
作者：
Francisco, Dave;Wang, Ying;Kraft, Monica
通讯作者：
Kraft, Monica
影响因子：
46.9
作者：
Chua, Robert Lorenz;Lukassen, Soeren;Eils, Roland
通讯作者：
Eils, Roland