Homocysteine, iron and cardiovascular disease: a hypothesis.
Homocysteine, iron and cardiovascular disease: a hypothesis.
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DOI：
10.3390/nu7021108
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发表时间：
2015-02-06
期刊：
影响因子：
5.9
通讯作者：
Tamura T
中科院分区：
文献类型：
--
作者：
Baggott JE;Tamura T
循环总同型半胱氨酸（tHcy）浓度升高（高同型半胱氨酸血症）已被视为心血管疾病（CVD）的独立危险因素。然而，几项使用B族维生素补充剂（特别是叶酸）纠正高同型半胱氨酸血症的大型临床试验在很大程度上未能降低CVD的风险。毫无疑问，大部分CVD患者存在高同型半胱氨酸血症;因此，可以合理地假设循环tHcy浓度在一定程度上是另一个尚未确定的CVD风险因素的替代标志物。我们发现，铁催化蛋氨酸，S-腺苷同型半胱氨酸和胱硫醚形成同型半胱氨酸。基于这些研究结果，我们提出，非蛋白结合铁（游离铁）的量增加循环tHcy。游离铁催化氧自由基的形成，氧化低密度脂蛋白是血管损伤的公认危险因素。在这篇综述中，我们讨论了我们的研究结果铁催化形成同型半胱氨酸硫醚以及最近的研究结果，其他调查人员在这个问题上。总的来说，这些支持了我们的假设，即循环tHcy是游离Fe的部分替代标志物，游离Fe是CVD的独立危险因素之一。
Elevated circulating total homocysteine (tHcy) concentrations (hyperhomocysteinemia) have been regarded as an independent risk factor for cardiovascular disease (CVD). However, several large clinical trials to correct hyperhomocysteinemia using B-vitamin supplements (particularly folic acid) have largely failed to reduce the risk of CVD. There is no doubt that a large segment of patients with CVD have hyperhomocysteinemia; therefore, it is reasonable to postulate that circulating tHcy concentrations are in part a surrogate marker for another, yet-to-be-identified risk factor(s) for CVD. We found that iron catalyzes the formation of Hcy from methionine, S-adenosylhomocysteine and cystathionine. Based on these findings, we propose that an elevated amount of non-protein-bound iron (free Fe) increases circulating tHcy. Free Fe catalyzes the formation of oxygen free radicals, and oxidized low-density lipoprotein is a well-established risk factor for vascular damage. In this review, we discuss our findings on iron-catalyzed formation of Hcy from thioethers as well as recent findings by other investigators on this issue. Collectively, these support our hypothesis that circulating tHcy is in part a surrogate marker for free Fe, which is one of the independent risk factors for CVD.
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影响因子：
5.9
作者：
Muñoz-Bravo C;Gutiérrez-Bedmar M;Gómez-Aracena J;García-Rodríguez A;Navajas JF
通讯作者：
Navajas JF
DOI：
10.1111/j.1440-1746.1992.tb01027.x
发表时间：
1992-09-01
影响因子：
4.1
作者：
NALINI, S;RAMAKRISHNA, BS;BALASUBRAMANIAN, KA
通讯作者：
BALASUBRAMANIAN, KA
影响因子：
4.7
作者：
Baggott, J. E.;Tamura, T.
通讯作者：
Tamura, T.
影响因子：
5.8
作者：
Lapice, Emanuela;Masulli, Maria;Vaccaro, Olga
通讯作者：
Vaccaro, Olga
影响因子：
158.5
作者：
CLARKE, R;DALY, L;GRAHAM, I
通讯作者：
GRAHAM, I