Iron: protector or risk factor for cardiovascular disease? Still controversial.
Iron: protector or risk factor for cardiovascular disease? Still controversial.
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DOI：
10.3390/nu5072384
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发表时间：
2013-07-01
期刊：
影响因子：
5.9
通讯作者：
Navajas JF
中科院分区：
文献类型：
--
作者：
Muñoz-Bravo C;Gutiérrez-Bedmar M;Gómez-Aracena J;García-Rodríguez A;Navajas JF
铁是地壳中第二丰富的金属。尽管以痕量存在，但它是人体必需的微量元素，尽管由于芬顿反应产生氧化应激，导致有机生物分子氧化，它也可能有毒。这个过程是许多病理学的基础，包括心血管疾病（CVD）。铁与心血管疾病的关系是由杰罗姆沙利文于1981年提出的。从那时起，已经进行了许多流行病学研究来验证这一假设。本综述的目的是介绍Sullivan提出铁假说以来32年来发表的主要流行病学研究的主要结果，表明铁元素可能是心血管疾病的危险因素。我们分析了55项研究，其中27项支持铁假说，20项没有证据支持它，8项与铁假说相反。我们的研究结果表明，没有高水平的证据支持铁可能与CVD相关的假设。尽管迄今为止发表了大量的研究，但由于结果的显著差异，铁在心血管疾病中的作用仍然引起了相当多的争论。
Iron is the second most abundant metal in the Earth’s crust. Despite being present in trace amounts, it is an essential trace element for the human body, although it can also be toxic due to oxidative stress generation by the Fenton reaction, causing organic biomolecule oxidation. This process is the basis of numerous pathologies, including cardiovascular diseases (CVD). The relationship between iron and cardiovascular disease was proposed in 1981 by Jerome Sullivan. Since then, numerous epidemiological studies have been conducted to test this hypothesis. The aim of this review is to present the main findings of the chief epidemiological studies published during the last 32 years, since Sullivan formulated his iron hypothesis, suggesting that this element might act as a risk factor for cardiovascular disease. We have analyzed 55 studies, of which 27 supported the iron hypothesis, 20 found no evidence to support it and eight were contrary to the iron hypothesis. Our results suggest that there is not a high level of evidence which supports the hypothesis that the iron may be associated with CVD. Despite the large number of studies published to date, the role of iron in cardiovascular disease still generates a fair amount of debate, due to a marked disparity in results.
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影响因子：
7.7
作者：
Marniemi, J;Järvisalo, J;Sourander, L
通讯作者：
Sourander, L
影响因子：
3.9
作者：
Leiva, Elba;Mujica, Veronica;Arredondo, Miguel A.
通讯作者：
Arredondo, Miguel A.
影响因子：
3.5
作者：
Manfroi, WC;Zago, AJ;Brizolara, ML
通讯作者：
Brizolara, ML
DOI：
10.3961/jpmph.2012.45.3.196
发表时间：
2012-05
期刊：
Journal of preventive medicine and public health = Yebang Uihakhoe chi
影响因子：
--
作者：
Kim KS;Son HG;Hong NS;Lee DH
通讯作者：
Lee DH
影响因子：
1.5
作者：
Holay, M P;Choudhary, A A;Suryawanshi, S D
通讯作者：
Suryawanshi, S D