Assessing Amyloid Pathology in Cognitively Normal Subjects Using (18)F-Flutemetamol PET: Comparing Visual Reads and Quantitative Methods.
Assessing Amyloid Pathology in Cognitively Normal Subjects Using (18)F-Flutemetamol PET: Comparing Visual Reads and Quantitative Methods.
复制标题
DOI：
10.2967/jnumed.118.211532
复制
发表时间：
2019-04
期刊：
影响因子：
--
通讯作者：
van Berckel BNM
中科院分区：
文献类型：
--
作者：
Collij LE;Konijnenberg E;Reimand J;Kate MT;Braber AD;Lopes Alves I;Zwan M;Yaqub M;van Assema DME;Wink AM;Lammertsma AA;Scheltens P;Visser PJ;Barkhof F;van Berckel BNM
我们的目标是确定评估认知正常老年人群淀粉样蛋白疾病的最佳方法。研究方法：动态18F-flutemetalone PET扫描获得使用咖啡休息协议（0- 30分钟扫描和90- 110分钟扫描）对190个认知正常的老年人（平均年龄，70.4岁，60%女性）。参数图像由SUV比率（SUVr）和不可置换结合电位（BPND）方法生成，小脑灰质作为参考区域，并由3名经过培训的阅片者进行视觉评估。使用κ-统计学计算阅片者间一致性，并获得半定量值。使用受试者操作特征分析和Youden指数计算SUVr和BPND的全局截止值。视觉评估与半定量分类有关。结果：SUVr视觉评估的阅片者间一致性为中等（κ = 0.57），BPND图像的阅片者间一致性为良好（κ = 0.77）。35例（18%）使用SUVr的阅片者与15例（8%）使用BPND的阅片者之间存在不一致，9例重叠。对于总队列，平均（±SD）SUVr和BPND分别为1.33（±0.21）和0.16（±0.12）。根据半定量测量，阅片者之间SUVr图像评估不一致的35例病例中的大多数（91%）被归类为阴性。结论：在低淀粉样蛋白负荷人群中使用参数化BPND图像进行18F-长笛测量的视觉评估可提高阅片者之间的一致性。实施半定量除了视觉评估的SUVr图像可以减少在这个群体中的假阳性分类。
Our objective was to determine the optimal approach for assessing amyloid disease in a cognitively normal elderly population. Methods: Dynamic 18F-flutemetamol PET scans were acquired using a coffee-break protocol (a 0- to 30-min scan and a 90- to 110-min scan) on 190 cognitively normal elderly individuals (mean age, 70.4 y; 60% female). Parametric images were generated from SUV ratio (SUVr) and nondisplaceable binding potential (BPND) methods, with cerebellar gray matter as a reference region, and were visually assessed by 3 trained readers. Interreader agreement was calculated using κ-statistics, and semiquantitative values were obtained. Global cutoffs were calculated for both SUVr and BPND using a receiver-operating-characteristic analysis and the Youden index. Visual assessment was related to semiquantitative classifications. Results: Interreader agreement in visual assessment was moderate for SUVr (κ = 0.57) and good for BPND images (κ = 0.77). There was discordance between readers for 35 cases (18%) using SUVr and for 15 cases (8%) using BPND, with 9 overlapping cases. For the total cohort, the mean (±SD) SUVr and BPND were 1.33 (±0.21) and 0.16 (±0.12), respectively. Most of the 35 cases (91%) for which SUVr image assessment was discordant between readers were classified as negative based on semiquantitative measurements. Conclusion: The use of parametric BPND images for visual assessment of 18F-flutemetamol in a population with low amyloid burden improves interreader agreement. Implementing semiquantification in addition to visual assessment of SUVr images can reduce false-positive classification in this population.
登录
查看更多内容
影响因子：
1.5
作者：
Buckley CJ;Sherwin PF;Smith AP;Wolber J;Weick SM;Brooks DJ
通讯作者：
Brooks DJ
影响因子：
9.9
作者：
Grothe MJ;Barthel H;Sepulcre J;Dyrba M;Sabri O;Teipel SJ;Alzheimer's Disease Neuroimaging Initiative
通讯作者：
Alzheimer's Disease Neuroimaging Initiative
影响因子：
4.2
作者：
Mountz, James M.;Laymon, Charles M.;Mathis, Chester A.
通讯作者：
Mathis, Chester A.
影响因子：
4
作者：
de Jager, CA;Budge, MM;Clarke, R
通讯作者：
Clarke, R
DOI：
10.1016/j.dadm.2017.06.001
发表时间：
2017-01-01
期刊：
Alzheimer's & dementia (Amsterdam, Netherlands)
影响因子：
--
作者：
Salloway, Stephen;Gamez, Jose E;Curtis, Craig
通讯作者：
Curtis, Craig