Viral infections in lung transplant recipients.
Viral infections in lung transplant recipients.
复制标题
DOI：
10.1055/s-0030-1249120
复制
发表时间：
2010-04
影响因子：
3.2
通讯作者：
McDyer JF
中科院分区：
文献类型：
--
作者：
Shah PD;McDyer JF
病毒感染，包括β-疱疹病毒和社区呼吸道病毒，是肺移植受者的常见病原体。这些病原体已被越来越多地认识到在肺移植的长期结果中具有重要作用，而肺移植的长期结果受到感染的频繁发展和慢性同种异体移植物功能障碍的限制。社区呼吸道病毒，如流感病毒和呼吸道合胞病毒与急性排斥反应和慢性同种异体移植物功能障碍有关，特别是如果没有进行早期治疗。β-疱疹病毒，特别是巨细胞病毒（CMV），长期以来一直与肺移植受者的死亡率增加有关，尽管有效的抗病毒策略的出现导致了发病率和死亡率的改善。由于这些病原体与针对同种异体移植物的免疫应答改变有关，因此更好地理解病毒感染的免疫发病机制可能会导致更广泛的方法来限制这些病原体的发病率。
Viral infections, including β-herpes viruses and community respiratory viruses, are frequent pathogens in lung transplant recipients. These pathogens have become increasingly recognized as having a significant role in long-term outcomes of lung transplantation, which has been limited by the frequent development of infections, and chronic allograft dysfunction. Community respiratory viruses, such as influenza and respiratory syncytial virus have been associated with both acute rejection and chronic allograft dysfunction, particularly if early treatment was not administered. β-herpes viruses, particularly cytomegalovirus (CMV), have long been associated with increased mortality in lung transplant recipients, although the advent of effective antiviral strategies has led to improved morbidity and mortality. Because these pathogens have been associated with altered immune responses against the allograft, a better understanding of immunopathogenesis of viral infections may lead to a broader approach to limit the morbidity from these pathogens.
登录
查看更多内容
影响因子：
20.3
作者：
Gamadia, LE;Remmerswaal, EBM;Ten Berge, IJM
通讯作者：
Ten Berge, IJM
影响因子：
5.8
作者：
Crowe, James E Jr;Williams, John V
通讯作者：
Williams, John V
影响因子：
20.3
作者：
Einsele, H;Roosnek, E;Hebart, H
通讯作者：
Hebart, H
DOI：
10.1016/0732-8893(88)90092-2
发表时间：
1988-08-01
影响因子：
2.9
作者：
ERICE, A;HERTZ, MI;BALFOUR, HH
通讯作者：
BALFOUR, HH
影响因子：
11.8
作者：
Chmiel, Corinne;Speich, Rudolf;Boehler, Annette
通讯作者：
Boehler, Annette