Hearing loss among HIV-seropositive and HIV-seronegative men and women.
Hearing loss among HIV-seropositive and HIV-seronegative men and women.
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DOI：
10.1001/jamaoto.2014.3302
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发表时间：
2015-03
影响因子：
7.8
通讯作者：
Plankey, Michael
中科院分区：
文献类型：
--
作者：
Torre, Peter, III;Hoffman, Howard J.;Springer, Gayle;Cox, Christopher;Young, Mary A.;Margolick, Joseph B.;Plankey, Michael
Hearing sensitivity among adults has quality of life implications as individuals become older. There are limited data on hearing loss among aging HIV+ adults. 1) To evaluate pure-tone hearing thresholds among HIV+ and HIV- adults with similar demographic characteristics. 2) To determine if HIV disease variables and antiretroviral therapy (ART) are associated with pure-tone threshold levels. 262 men (117 HIV+) from the Baltimore/Washington, DC site of the Multicenter AIDS Cohort Study (MACS) and 134 women (105 HIV+) from the Washington, DC site of the Women's Interagency HIV Study (WIHS) participated. Pure-tone air-conduction thresholds were collected in a sound-treated room at octave frequencies from 250 through 8000 Hz, along with interoctave frequencies of 750, 3000, and 6000 Hz. None. In each ear, a low-frequency pure-tone average (LPTA) was calculated using air-conduction thresholds at 250, 500, 1000, and 2000 Hz and a high-frequency PTA (HPTA) was calculated using air-conduction thresholds at 3000, 4000, 6000, and 8000 Hz. Linear mixed regression models tested the effect of HIV on hearing after adjusting for age, sex, race, and noise exposure history. Differential HIV effects for LPTA and HPTA and better/worse ear were also examined. CD4+ and CD8+ T-cell counts, log10 plasma HIV RNA concentrations, ever having had an AIDS-defining condition, and cumulative time on ART were included in the models for HIV+ participants only. HPTA and LPTA were significantly higher (18% and 12%, respectively), for HIV+ participants compared to HIV- participants for the better ear. The direction of the effect was consistent across both the better and worse ear. There were no significant associations between HIV disease variables or treatment variables and LPTA or HPTA. HIV+ adults had significantly poorer lower and higher frequency hearing compared to HIV- adults. High frequency hearing loss is consistent with an accelerated aging (presbycusis); hearing loss in the low frequency range among middle-aged individuals is an unexpected finding. Since some vowels and consonants have predominantly low frequency acoustic energy, poorer hearing in lower frequencies may lead to increased communication difficulties in HIV+ individuals.
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影响因子：
2.5
作者：
Chandrasekhar, SS;Connelly, PE;Baredes, S
通讯作者：
Baredes, S
影响因子：
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Brown, TT;Cole, SR;Dobs, AS
通讯作者：
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2.4
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KEWLEYPORT, D
通讯作者：
KEWLEYPORT, D
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3.7
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Schouten JT;Lockhart DW;Rees TS;Collier AC;Marra CM
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Marra CM
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Barkan, SE;Melnick, SL;Feldman, J
通讯作者：
Feldman, J