B7-h3 and its role in antitumor immunity.

B7-h3 and its role in antitumor immunity.
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DOI:
10.1155/2010/683875
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发表时间:
2010
影响因子:
--
通讯作者:
Kleeff J
Kleeff J
中科院分区:
其他
文献类型:
--
作者:
Loos M;Hedderich DM;Friess H;Kleeff J

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B7-H3是最近发现的B7/CD28共刺激分子超家族成员之一,作为T细胞反应的辅助调节器。最近,B7-H3在几种人类癌症中的表达被报道,这表明B7-H3作为抗肿瘤免疫调节因子具有额外的功能。然而,其确切的生理作用仍然难以捉摸,因为刺激和抑制能力都已被证明。本文综述了B7-H3在调节T细胞反应方面的现有资料,重点介绍了其在抗肿瘤免疫中的潜在作用。
B7-H3 is one of the most recently identified members of the B7/CD28 superfamily of costimulatory molecules serving as an accessory modulator of T-cell response. Recently, B7-H3 expression has been reported in several human cancers indicating an additional function of B7-H3 as a regulator of antitumor immunity. However, its precise physiologic role is still elusive, because both stimulatory and inhibitory capacities have been demonstrated. This paper summarizes the available data on B7-H3 in the regulation of T-cell response focusing on its potential role in antitumor immunity.
DOI: 10.1158/1078-0432.ccr-09-0265
发表时间: 2009-09-01
期刊: Clinical cancer research : an official journal of the American Association for Cancer Research
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