Hippocampal subfield volumes are nonspecifically reduced in premature-born adults.
Hippocampal subfield volumes are nonspecifically reduced in premature-born adults.
复制标题
DOI：
10.1002/hbm.25187
复制
发表时间：
2020-12-15
影响因子：
4.8
通讯作者：
Sorg C
中科院分区：
文献类型：
--
作者：
Hedderich DM;Avram M;Menegaux A;Nuttall R;Zimmermann J;Schneider SC;Schmitz-Koep B;Daamen M;Scheef L;Boecker H;Zimmer C;Baumann N;Bartmann P;Wolke D;Bäuml JG;Sorg C
从新生儿到成年人，早产个体的整体海马体积已经被证明减少;然而，海马子区（HCSF）体积是否受到早产的不同影响以及它们与认知表现的相关性尚不清楚。为了解决这些问题，我们研究了非常早产的成年人的磁共振成像（MRI）衍生的HCSF体积，并将其与成年后的一般认知表现相关联。我们评估了103名极早产儿（胎龄[GA] <32周和/或出生体重<1，500 g）和109名足月出生的个体，他们在26岁时进行了认知测试和结构MRI。基于三维T1和T2加权序列自动分割HCSF，并将其单独研究并分组为三个功能单元，即海马体（HP），下托复合体（SC）和齿状回（DG）。使用韦氏成人智力量表（全量表智商[FS-IQ]）测量26岁时的认知能力。我们观察到早产成人几乎所有HCSF体积的双侧体积减少以及与GA和新生儿治疗强度的相关性，但与出生体重无关。左侧HP、SC和DG体积与成人FS-IQ相关。此外，左DG体积是早产儿GA和成人FS-IQ之间关联的中介。结果表明，非特异性减少HCSF体积早产的成年人，但与认知结果的具体关联突出了左DG的重要性。数据表明，对海马功能的特定干预可能有希望降低早产儿的不良认知影响。Hedderich等人报告了早产成年人海马子域体积的非特异性减少。然而，他们发现减少的齿状回体积介导了低胎龄对成人全面智商的影响，这表明早产儿成人的功能相关性。
Reduced global hippocampus volumes have been demonstrated in premature‐born individuals, from newborns to adults; however, it is unknown whether hippocampus subfield (HCSF) volumes are differentially affected by premature birth and how relevant they are for cognitive performance. To address these questions, we investigated magnetic resonance imaging (MRI)‐derived HCSF volumes in very premature‐born adults, and related them with general cognitive performance in adulthood. We assessed 103 very premature‐born (gestational age [GA] <32 weeks and/or birth weight <1,500 g) and 109 term‐born individuals with cognitive testing and structural MRI at 26 years of age. HCSFs were automatically segmented based on three‐dimensional T1‐ and T2‐weighted sequences and studied both individually and grouped into three functional units, namely hippocampus proper (HP), subicular complex (SC), and dentate gyrus (DG). Cognitive performance was measured using the Wechsler‐Adult‐Intelligence‐Scale (full‐scale intelligence quotient [FS‐IQ]) at 26 years. We observed bilateral volume reductions for almost all HCSF volumes in premature‐born adults and associations with GA and neonatal treatment intensity but not birth weight. Left‐sided HP, SC, and DG volumes were associated with adult FS‐IQ. Furthermore, left DG volume was a mediator of the association between GA and adult FS‐IQ in premature‐born individuals. Results demonstrate nonspecifically reduced HCSF volumes in premature‐born adults; but specific associations with cognitive outcome highlight the importance of the left DG. Data suggest that specific interventions toward hippocampus function might be promising to lower adverse cognitive effects of prematurity. Hedderich et al. report unspecific reductions of hippocampus subfield volumes in premature‐born adults. However, they found reduced dentate gyrus volumes to mediate the effect of low gestational age on adult full‐scale intelligence quotient suggesting functional relevance in premature‐born adults.
登录
查看更多内容
影响因子：
6.3
作者：
Bartsch, Thorsten;Doehring, Juliane;Jansen, Olav
通讯作者：
Jansen, Olav
影响因子：
3.7
作者：
Cole JH;Filippetti ML;Allin MP;Walshe M;Nam KW;Gutman BA;Murray RM;Rifkin L;Thompson PM;Nosarti C
通讯作者：
Nosarti C
影响因子：
3.5
作者：
Becker, S
通讯作者：
Becker, S
影响因子：
3.1
作者：
Bjuland, Knut J.;Rimol, Lars M.;Skranes, Jon
通讯作者：
Skranes, Jon
影响因子：
4.2
作者：
Aanes, Synne;Bjuland, Knut Jorgen;Skranes, Jon
通讯作者：
Skranes, Jon