Subregional Hippocampal Morphology and Psychiatric Outcome in Adolescents Who Were Born Very Preterm and at Term.
Subregional Hippocampal Morphology and Psychiatric Outcome in Adolescents Who Were Born Very Preterm and at Term.
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DOI：
10.1371/journal.pone.0130094
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Nosarti C
中科院分区：
文献类型：
--
作者：
Cole JH;Filippetti ML;Allin MP;Walshe M;Nam KW;Gutman BA;Murray RM;Rifkin L;Thompson PM;Nosarti C
据报道，作为早产儿(妊娠33周)的后遗症，海马体在结构和功能上都发生了改变，这可能是因为它在新生儿期容易受到缺氧缺血的损害。我们研究了青春期中期和晚期早产儿的海马体体积和亚区形态，以及它们与精神结局的关系。对65名早产儿(平均年龄15.5岁和19.6岁)和36名足月儿对照组(平均年龄15.0岁和19.0岁)在两个时间点(基线和随访)进行脑磁共振结构成像。通过手动描记和三维形状分析测量海马体体积和亚区形态计量学差异。在基线时使用Rutter父母量表，在随访时使用一般健康问卷，在两个时间点使用彼得斯妄想症问卷来评估精神结果。与以前的研究相比，我们没有发现早产儿和对照组之间在横断面或纵向的海马体体积上的显著差异，尽管早产儿的整个脑体积明显较小。基线时的形状分析显示，与对照组相比，早产儿组和随访时的22%的早产儿双侧海马区总表面积的28%出现了次区域变形，反映了萎缩。在早产儿中，海马体形状的纵向变化占总表面积的11%，而在对照组达到20%。在整个样本中(两组)，基线时右侧海马体体积较大和双侧前表面变形与随访时的妄想症评分相关。这项研究表明，海马体横截面体积、纵向变化和表面变形与精神病倾向之间存在动态关联。
The hippocampus has been reported to be structurally and functionally altered as a sequel of very preterm birth (<33 weeks gestation), possibly due its vulnerability to hypoxic–ischemic damage in the neonatal period. We examined hippocampal volumes and subregional morphology in very preterm born individuals in mid- and late adolescence and their association with psychiatric outcome. Structural brain magnetic resonance images were acquired at two time points (baseline and follow-up) from 65 ex-preterm adolescents (mean age = 15.5 and 19.6 years) and 36 term-born controls (mean age=15.0 and 19.0 years). Hippocampal volumes and subregional morphometric differences were measured from manual tracings and with three-dimensional shape analysis. Psychiatric outcome was assessed with the Rutter Parents’ Scale at baseline, the General Health Questionnaire at follow-up and the Peters Delusional Inventory at both time points. In contrast to previous studies we did not find significant difference in the cross-sectional or longitudinal hippocampal volumes between individuals born preterm and controls, despite preterm individual having significantly smaller whole brain volumes. Shape analysis at baseline revealed subregional deformations in 28% of total bilateral hippocampal surface, reflecting atrophy, in ex-preterm individuals compared to controls, and in 22% at follow-up. In ex-preterm individuals, longitudinal changes in hippocampal shape accounted for 11% of the total surface, while in controls they reached 20%. In the whole sample (both groups) larger right hippocampal volume and bilateral anterior surface deformations at baseline were associated with delusional ideation scores at follow-up. This study suggests a dynamic association between cross-sectional hippocampal volumes, longitudinal changes and surface deformations and psychosis proneness.
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影响因子：
--
作者：
Blumberg, HP;Kaufman, J;Peterson, BS
通讯作者：
Peterson, BS
影响因子：
3.5
作者：
Barbas, H;Blatt, GJ
通讯作者：
Blatt, GJ
影响因子：
4.2
作者：
Eisenberger, Naomi I.;Gable, Shelly L.;Lieberman, Matthew D.
通讯作者：
Lieberman, Matthew D.
影响因子：
5.2
作者：
Abernethy, LJ;Palaniappan, M;Cooke, RWI
通讯作者：
Cooke, RWI
DOI：
10.1073/pnas.1015950108
发表时间：
2011-02-15
影响因子：
11.1
作者：
Erickson, Kirk I.;Voss, Michelle W.;Kramer, Arthur F.
通讯作者：
Kramer, Arthur F.