Homeostatic regulation of marginal zone B cells by invariant natural killer T cells.
Homeostatic regulation of marginal zone B cells by invariant natural killer T cells.
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DOI：
10.1371/journal.pone.0026536
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Singh RR
中科院分区：
文献类型：
--
作者：
Wen X;Yang JQ;Kim PJ;Singh RR
Marginal zone B cells (MZB) mount a rapid antibody response, potently activate naïve T cells, and are enriched in autoreactive B cells. MZBs express high levels of CD1d, the restriction element for invariant natural killer T cells (iNKT). Here, we examined the effect of iNKT cells on MZB cell activation and numbers in vitro and in vivo in normal and autoimmune mice. Results show that iNKT cells activate MZBs, but restrict their numbers in vitro and in vivo in normal BALB/c and C57/BL6 mice. iNKT cells do so by increasing the activation-induced cell death and curtailing proliferation of MZB cells, whereas they promote the proliferation of follicular B cells. Sorted iNKT cells can directly execute this function, without help from other immune cells. Such MZB regulation by iNKTs is mediated, at least in part, via CD1d on B cells in a contact-dependent manner, whereas iNKT-induced proliferation of follicular B cells occurs in a contact- and CD1d-independent manner. Finally, we show that iNKT cells reduce ‘autoreactive’ MZB cells in an anti-DNA transgenic model, and limit MZB cell numbers in autoimmune-prone (NZB×NZW)F1 and non-obese diabetic mice, suggesting a potentially new mechanism whereby iNKT cells might regulate pathologic autoimmunity. Differential regulation of follicular B cells versus potentially autoreactive MZBs by iNKT cells has important implications for autoimmune diseases as well as for conditions that require a rapid innate B cell response.
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DOI：
10.1084/jem.20020223
发表时间：
2002-09-16
期刊：
The Journal of experimental medicine
影响因子：
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作者：
Fan GC;Singh RR
通讯作者：
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影响因子：
11.2
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DOI：
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发表时间：
2001-10-15
期刊：
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影响因子：
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作者：
Hao Z;Rajewsky K
通讯作者：
Rajewsky K
DOI：
10.1084/jem.20011453
发表时间：
2002-01-21
期刊：
The Journal of experimental medicine
影响因子：
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作者：
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通讯作者：
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DOI：
10.1073/pnas.0700191104
发表时间：
2007-03-06
影响因子：
11.1
作者：
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通讯作者：
Abrignani, Sergio