Homeostasis of peripheral B cells in the absence of B cell influx from the bone marrow.
Homeostasis of peripheral B cells in the absence of B cell influx from the bone marrow.
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DOI：
10.1084/jem.194.8.1151
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发表时间：
2001-10-15
期刊：
影响因子：
--
通讯作者：
Rajewsky K
中科院分区：
文献类型：
--
作者：
Hao Z;Rajewsky K
为了研究在没有来自骨髓的B细胞流入的情况下外周B淋巴细胞的稳态，我们产生了重组激活基因（RAG）-2可诱导缺失的小鼠突变体。当RAG-2在8-10周龄时被删除时，脾幼稚滤泡B细胞在一年的观察中逐渐丢失，半衰期为1.45个月。相反，脾脏中的边缘区B细胞池和腹腔中的B-1细胞池保持在正常水平。淋巴结中B细胞在4个月内丢失约90%，此后B细胞数量保持不变。出生时RAG-2缺失的小鼠维持少量活化B细胞，边缘区B细胞比例增加。此外，观察到IgM分泌细胞和B-1a细胞池增加。
To study homeostasis of peripheral B lymphocytes in the absence of B cell influx from the bone marrow, we generated a mouse mutant in which the recombination-activating gene (RAG)-2 can be inducibly deleted. When RAG-2 was deleted at the age of 8–10 wk, splenic naive follicular B cells were gradually lost over a year of observation, with a half-life of ∼4.5 mo. By contrast, the pool of marginal zone B cells in the spleen and of B-1 cells in the peritoneal cavity were kept at normal level. In lymph nodes, ∼90% of the B cells were lost within 4 mo, and B cell numbers remained constant thereafter. Mice in which RAG-2 was deleted at birth maintained a small population of activated B cells with an increased proportion of marginal zone B cells. Additionally, an increase of the pool of IgM secreting cells and B-1a cells was observed.
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DOI：
10.1084/jem.154.3.994
发表时间：
1981-09-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
de Freitas AA;Coutinho A
通讯作者：
Coutinho A
影响因子：
5.4
作者：
FORSTER, I;MULLER, W;RAJEWSKY, K
通讯作者：
RAJEWSKY, K
影响因子：
4.4
作者：
Kroese, Frans G. M.;Butcher, Eugene C.;Herzenberg, Leonore A.
通讯作者：
Herzenberg, Leonore A.
影响因子：
2.2
作者：
CZERKINSKY, CC;NILSSON, LA;TARKOWSKI, A
通讯作者：
TARKOWSKI, A
DOI：
10.1073/pnas.87.12.4781
发表时间：
1990-06-01
影响因子：
11.1
作者：
FORSTER, I;RAJEWSKY, K
通讯作者：
RAJEWSKY, K