Identification of a Retinal Circuit for Recurrent Suppression Using Indirect Electrical Imaging.
Identification of a Retinal Circuit for Recurrent Suppression Using Indirect Electrical Imaging.
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DOI：
10.1016/j.cub.2016.05.051
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发表时间：
2016-08-08
期刊：
影响因子：
9.2
通讯作者：
Chichilnisky, E. J.
中科院分区：
文献类型：
--
作者：
Greschner, Martin;Heitman, Alexander K.;Field, Greg D.;Li, Peter H.;Ahn, Daniel;Sher, Alexander;Litke, Alan M.;Chichilnisky, E. J.
了解调节性神经元间网络的功能是一个重大挑战，因为这类网络通常运行在长空间尺度上，涉及许多不同类型的神经元。在这里，我们使用间接的电成像方法来揭示由两种细胞类型组成的空间延伸的、经常性的视网膜回路的功能。这种循环回路在灵长类大细胞视觉通路中产生早期视觉信号的外周反应抑制。我们通过其独特的电信号从生理上识别了一种多轴突无长突细胞，这是通过与使用大规模多电极阵列记录的视网膜节细胞的电耦合而揭示的。耦合导致无长突细胞发射长距离辐射传播的棘波，对记录在无长突细胞轴突投射附近的遮盖细胞产生GABA能抑制。我们提出并验证了这种类型的无长突细胞的功能模型，在该模型中，阳伞细胞的超经典感受野是通过电耦合的无长突细胞网络与周围的阳伞细胞相互抑制而形成的。Greschner等人。在灵长类动物的大细胞视觉通路中，发现了一种无长突神经亚路，它反复调节视网膜神经节细胞的活动。无长突细胞与阳伞细胞电耦合，它们的信号在很长的距离上传播，产生对远处阳伞细胞的相互抑制。
Understanding the function of modulatory interneuron networks is a major challenge, because such networks typically operate over long spatial scales and involve many neurons of different types. Here we use an indirect electrical imaging method to reveal the function of a spatially extended, recurrent retinal circuit composed of two cell types. This recurrent circuit produces peripheral response suppression of early visual signals in the primate magnocellular visual pathway. We identify a type of polyaxonal amacrine cell physiologically via its distinctive electrical signature, revealed by electrical coupling with ON parasol retinal ganglion cells recorded using a large-scale multi-electrode array. Coupling causes the amacrine cells to fire spikes that propagate radially over long distances, producing GABA-ergic inhibition of other ON parasol cells recorded near the amacrine cell axonal projections. We propose and test a model for the function of this amacrine cell type, in which the extra-classical receptive field of ON parasol cells is formed by reciprocal inhibition from other ON parasol cells in the periphery, via the electrically coupled amacrine cell network. Greschner et al. discovered an amacrine subcircuit that recurrently modulates the activity of retinal ganglion cells in the magnocellular visual pathway of primates. The amacrine cells are electrically coupled to ON-parasol cells, and their signals propagate over long distances, producing reciprocal inhibition of distant ON-parasol cells.
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影响因子：
64.8
作者：
Pillow JW;Shlens J;Paninski L;Sher A;Litke AM;Chichilnisky EJ;Simoncelli EP
通讯作者：
Simoncelli EP
影响因子：
5.5
作者：
Greschner, Martin;Shlens, Jonathon;Chichilnisky, E. J.
通讯作者：
Chichilnisky, E. J.
影响因子：
5.3
作者：
Marc, RE;Jones, BW
通讯作者：
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影响因子：
16.2
作者：
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通讯作者：
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影响因子：
1.9
作者：
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通讯作者：
BRACE, S