Cortical dendritic activity correlates with spindle-rich oscillations during sleep in rodents.
Cortical dendritic activity correlates with spindle-rich oscillations during sleep in rodents.
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DOI：
10.1038/s41467-017-00735-w
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发表时间：
2017-09-25
影响因子：
16.6
通讯作者：
Larkum ME
中科院分区：
文献类型：
--
作者：
Seibt J;Richard CJ;Sigl-Glöckner J;Takahashi N;Kaplan DI;Doron G;de Limoges D;Bocklisch C;Larkum ME
睡眠如何影响大脑可塑性尚不清楚。特别是，为什么某些脑电图（EEG）节律与记忆巩固有关，人们还知之甚少。树突中的钙活动是结构可塑性变化所必需的，但这在睡眠中从未被仔细检查过。在这里，我们报告说，在自然睡眠的啮齿类动物的纺锤体范围内的振荡过程中，新皮质树突的种群中的钙活性增加和同步。值得注意的是，在相同神经元的细胞体和整个皮质柱中没有发现相同的关系。睡眠中的痉挛被认为对大脑发育和可塑性很重要。我们的研究结果提供了证据，在特定的树突，突触可塑性的主要网站皮层纺锤体的生理联系。睡眠的不同阶段，由特定的脑电图（EEG）签名标记，已与记忆巩固有关，但其潜在机制知之甚少。在这里，作者表明树突状钙同步与纺锤体丰富的睡眠阶段相关。
How sleep influences brain plasticity is not known. In particular, why certain electroencephalographic (EEG) rhythms are linked to memory consolidation is poorly understood. Calcium activity in dendrites is known to be necessary for structural plasticity changes, but this has never been carefully examined during sleep. Here, we report that calcium activity in populations of neocortical dendrites is increased and synchronised during oscillations in the spindle range in naturally sleeping rodents. Remarkably, the same relationship is not found in cell bodies of the same neurons and throughout the cortical column. Spindles during sleep have been suggested to be important for brain development and plasticity. Our results provide evidence for a physiological link of spindles in the cortex specific to dendrites, the main site of synaptic plasticity. Different stages of sleep, marked by particular electroencephalographic (EEG) signatures, have been linked to memory consolidation, but underlying mechanisms are poorly understood. Here, the authors show that dendritic calcium synchronisation correlates with spindle-rich sleep phases.
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影响因子：
3
作者：
Lachaux, JP;Chavez, M;Lutz, A
通讯作者：
Lutz, A
DOI：
10.1073/pnas.0910379106
发表时间：
2009-12-01
影响因子：
11.1
作者：
Murayama, Masanori;Larkum, Matthew E.
通讯作者：
Larkum, Matthew E.
DOI：
10.1523/jneurosci.2604-11.2011
发表时间：
2011-12-07
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Andrillon T;Nir Y;Staba RJ;Ferrarelli F;Cirelli C;Tononi G;Fried I
通讯作者：
Fried I
影响因子：
2.5
作者：
Contreras, D;Destexhe, A;Steriade, M
通讯作者：
Steriade, M
影响因子：
5.3
作者：
Le Van Quyen, Michel;Staba, Richard;Engel, Jerome
通讯作者：
Engel, Jerome