Tumor subtype-specific associations of hormone-related reproductive factors on breast cancer survival.
Tumor subtype-specific associations of hormone-related reproductive factors on breast cancer survival.
复制标题
DOI：
10.1371/journal.pone.0123994
复制
发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Kang D
中科院分区：
文献类型：
--
作者：
Song N;Choi JY;Sung H;Jeon S;Chung S;Song M;Park SK;Han W;Lee JW;Kim MK;Yoo KY;Ahn SH;Noh DY;Kang D
被称为乳腺癌危险因素的生殖因素是否也会影响生存尚无定论。我们调查了生殖因素与乳腺癌生存之间的总体和亚型特异性关联。在参加首尔乳腺癌研究的 3,430 名乳腺癌患者中，269 名患者（7.8%）死亡，528 名患者（15.4%）复发。使用多变量 Cox 比例风险，通过风险比 (HR) 和 95% 置信区间 (95% CI) 估计生殖因素（包括初潮和绝经年龄、雌激素暴露持续时间、月经周期、产次、首次足月妊娠年龄、儿童数量、上次生育年龄、距上次生育时间和母乳喂养持续时间）与总体生存率和无病生存率 (OS 和 DFS) 的总体和亚型特异性关联模型。初潮年龄较大（OS=1.10，95% CI=1.03-1.19），子女数量较多（≥4 vs. 2，DFS=1.58，95% CI=1.11-2.26），自上次生育以来的时间较短（<5 vs. ≥20 年，DFS=1.67，95% CI=1.07-2.62）与较差的生存率相关，而较长的雌激素暴露时间与较好的生存率相关（DFS的HR=0.97，95% CI=0.96-0.99）。在按亚型进行的分层分析中，这些关联在患有激素受体和人表皮生长因子 2 阳性 (HR+ HER2+) 肿瘤的女性中更为明显。研究表明，生殖因素，特别是初潮年龄、孩子数量、距上次生育的时间以及雌激素暴露持续时间，可能会影响乳腺肿瘤的进展，尤其是在 HR+ HER2+ 亚型中。
It is inconclusive whether reproductive factors, which are known as risk factors of breast cancer, also influence survival. We investigated overall and subtype-specific associations between reproductive factors and breast cancer survival. Among 3,430 incident breast cancer patients who enrolled in the Seoul Breast Cancer Study, 269 patients (7.8%) died and 528 patients (15.4%) recurred. The overall and subtype-specific associations of reproductive factors including age at menarche and menopause, duration of estrogen exposure, menstrual cycle, parity, age at first full-term pregnancy, number of children, age at last birth, time since the last birth, and duration of breastfeeding, on overall and disease-free survival (OS and DFS) were estimated by hazard ratios (HRs) and 95% confidence intervals (95% CIs) using a multivariate Cox proportional hazard model. An older age at menarche (HR for OS=1.10, 95% CI=1.03-1.19), a greater number of children (≥4 vs. 2, HR for DFS=1.58, 95% CI=1.11-2.26), and a shorter time since last birth (<5 vs. ≥20 years, HR for DFS=1.67, 95% CI=1.07-2.62) were associated with worse survival while longer duration of estrogen exposure with better survival (HR for DFS=0.97, 95% CI=0.96-0.99). In the stratified analyses by subtypes, those associations were more pronounced among women with hormone receptor and human epidermal growth factor 2 positive (HR+ HER2+) tumors. It is suggested that reproductive factors, specifically age at menarche, number of children, time since last birth, and duration of estrogen exposure, could influence breast tumor progression, especially in the HR+ HER2+ subtype.
登录
查看更多内容
影响因子：
3.8
作者：
Andersen, S. Warren;Newcomb, P. A.;Hampton, J. M.;Titus-Ernstoff, L.;Egan, K. M.;Trentham-Dietz, A.
通讯作者：
Trentham-Dietz, A.
影响因子：
13.6
作者：
Jaffe, Dena H.;Neumark, Yehuda D.;Manor, Orly
通讯作者：
Manor, Orly
DOI：
10.1038/nrrheum.2014.36
发表时间：
2014-07
期刊：
Nature reviews. Rheumatology
影响因子：
--
作者：
通讯作者：
--
影响因子：
3.8
作者：
Anderson, Kristin N.;Schwab, Richard B.;Martinez, Maria Elena
通讯作者：
Martinez, Maria Elena
影响因子：
7.2
作者：
Brisken, Cathrin;O'Malley, Bert
通讯作者：
O'Malley, Bert