Reproductive risk factors and breast cancer subtypes: a review of the literature.
Reproductive risk factors and breast cancer subtypes: a review of the literature.
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DOI：
10.1007/s10549-014-2852-7
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发表时间：
2014-02
影响因子：
3.8
通讯作者：
Martinez, Maria Elena
中科院分区：
文献类型：
--
作者：
Anderson, Kristin N.;Schwab, Richard B.;Martinez, Maria Elena
除了年龄、性别和家族史外，患乳腺癌的风险在很大程度上与生殖因素有关，生殖因素是性激素暴露的特征。鉴于目前在肿瘤水平上的分子检测是可能的，肿瘤亚型的临床特征通常用于指导治疗决策。然而，尽管发表了大量关于生殖因素与乳腺癌风险关联的观察性研究数据，但关于乳腺癌亚型特异性关联的报道相对较少。我们回顾了文献，总结了生殖因素与三种不同肿瘤亚型（雌激素受体/孕激素受体阳性（激素受体阳性，HR+肿瘤）、过表达人表皮受体2蛋白（HER2+）的肿瘤和缺乏这三种标志物的三阴性乳腺癌（TNBC））的风险或几率之间的关系。结果显示，HR+乳腺癌与生殖危险因素相关的证据最为一致，其中，未生育、目前使用绝经期激素治疗（HT）、月经初潮和初产年龄间隔过长是最强的危险因素；初生年龄增加和初潮年龄减少与HR+癌症的相关性相当一致；尽管不太一致，绝经年龄也与HR+肿瘤呈正相关，而哺乳期与HR+肿瘤呈负相关。TNBC的一致性关联报道较少。与TNBC最一致的单一保护因素是母乳喂养时间较长。胎次增加、初产年龄更小、初潮年龄更大以及口服避孕药的使用与TNBC的相关性不太一致。尽管基于相对较少的数据，HER2+乳腺癌没有明显的关联。研究结果表明，乳腺肿瘤不同亚型的生殖危险因素存在异质性，这可能对推荐的预防策略有影响。
Aside from age, sex, and family history, risk of developing breast cancer is largely linked to reproductive factors, which characterize exposure to sex hormones. Given that molecular testing at the tumor level is currently possible, clinical characterization of tumor subtypes is routinely conducted to guide treatment decisions. However, despite the vast amount of published data from observational studies on reproductive factor associations and breast cancer risk, relatively fewer reports have been published on associations specific to breast tumor subtypes. We conducted a review of the literature and summarized the results of associations between reproductive factors and risk or odds of three distinct tumor subtypes: estrogen receptor/progesterone receptor positive (hormone receptor positive, HR+ tumors), tumors overexpressing the human epidermal receptor 2 protein (HER2+), and triple negative breast cancer (TNBC), which lacks the three markers. Results show that the most consistent evidence for associations with reproductive risk factors exists for HR+ breast cancers, with nulliparity, current use of menopausal hormone therapy (HT), and prolonged interval between menarche and age at first birth being the strongest risk factors; increased age at first birth and decreased age at menarche were fairly consistently associated with HR+ cancers; and though less consistent, older age at menopause was also positively associated, while lactation was inversely associated with HR+ tumors. Fewer consistent associations have been reported for TNBC. The single protective factor most consistently associated with TNBC was longer duration of breastfeeding. Increased parity, younger age at first birth, older age at menarche, and oral contraceptive use were less consistently shown to be associated with TNBC. No remarkable associations for HER2+ breast cancers were evident although this was based on relatively scarce data. Findings suggest heterogeneity in reproductive risk factors for the distinct subtypes of breast tumors, which may have implications for recommended prevention strategies.
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影响因子：
3.9
作者：
Elsawaf, Zeinab;Sinn, Hans-Peter;Aulmann, Sebastian
通讯作者：
Aulmann, Sebastian
影响因子：
3.8
作者：
Gaudet MM;Press MF;Haile RW;Lynch CF;Glaser SL;Schildkraut J;Gammon MD;Douglas Thompson W;Bernstein JL
通讯作者：
Bernstein JL
影响因子：
50.5
作者：
Islam, T.;Matsuo, K.;Tanaka, H.
通讯作者：
Tanaka, H.
DOI：
10.1158/1055-9965.epi-10-0742
发表时间：
2010-11
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Martínez ME;Cruz GI;Brewster AM;Bondy ML;Thompson PA
通讯作者：
Thompson PA
DOI：
10.1186/bcr3218
发表时间：
2012-07-03
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Lecarpentier J;Noguès C;Mouret-Fourme E;Gauthier-Villars M;Lasset C;Fricker JP;Caron O;Stoppa-Lyonnet D;Berthet P;Faivre L;Bonadona V;Buecher B;Coupier I;Gladieff L;Gesta P;Eisinger F;Frénay M;Luporsi E;Lortholary A;Colas C;Dugast C;Longy M;Pujol P;Tinat J;GENEPSO;Lidereau R;Andrieu N
通讯作者：
Andrieu N