Intensity- and timing-dependent modulation of motion perception with transcranial magnetic stimulation of visual cortex.
Intensity- and timing-dependent modulation of motion perception with transcranial magnetic stimulation of visual cortex.
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DOI：
10.1016/j.neuropsychologia.2020.107581
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发表时间：
2020-10
期刊：
影响因子：
2.6
通讯作者：
Appelbaum LG
中科院分区：
文献类型：
--
作者：
Gamboa Arana OL;Palmer H;Dannhauer M;Hile C;Liu S;Hamdan R;Brito A;Cabeza R;Davis SW;Peterchev AV;Sommer MA;Appelbaum LG
尽管经颅磁刺激(TMS)在研究和临床护理中得到了广泛的应用，但其调节效应的剂量-反应关系和神经生理学相关性仍然相对未知。为了填补这一空白，我们研究了视觉加工作为TMS参数的函数的调制。我们的方法结合了脑电(EEG)和单脉冲TMS在受试者进行运动感知任务时对视皮层的应用。在每个参与者的第一次访问中，测量运动连贯阈值、通道视觉诱发电位(VEP)和TMS静息运动阈值。在第二次和第三次检查中，单脉冲TMS在两个潜伏期中的一个被提供，或者在运动开始之前30ms，或者在从第一次治疗中得出的N2VEP成分的开始潜伏期。TMS在N2峰活性部位的RMT为0%、80%、100%或120%，或在顶点上方为120%。行为学结果表明，TMS计时对准确度有显著的主效应，当TMS在氮气开始计时应用时的表现优于在氮气开始时的表现，以及显著的交互作用，表明80%的强度在氮气开始时产生比其他条件更高的准确率。TMS对P3VEP的影响表现为80%起病前波幅降低，120%氮气起效时波幅增加，且波幅随刺激强度单调变化。氮气组分不受TMS影响。这些发现揭示了TMS强度和时间对视觉知觉和电生理反应的影响，在RMT以下的刺激强度下具有最佳的促进作用。
Despite the widespread use of transcranial magnetic stimulation (TMS) in research and clinical care, the dose–response relations and neurophysiological correlates of modulatory effects remain relatively unexplored. To fill this gap, we studied modulation of visual processing as a function of TMS parameters. Our approach combined electroencephalography (EEG) with application of single pulse TMS to visual cortex as participants performed a motion perception task. During each participants’ first visit, motion coherence thresholds, 64-channel visual evoked potentials (VEPs), and TMS resting motor thresholds (RMT) were measured. In second and third visits, single pulse TMS was delivered at one of two latencies, either 30 ms before the onset of motion or at the onset latency of the N2 VEP component derived from the first session. TMS was delivered at 0%, 80%, 100%, or 120% of RMT over the site of N2 peak activity, or at 120% over vertex. Behavioral results demonstrated a significant main effect of TMS timing on accuracy, with better performance when TMS was applied at the N2-Onset timing versus Pre-Onset, as well as a significant interaction, indicating that 80% intensity produced higher accuracy than other conditions at the N2-Onset. TMS effects on the P3 VEP showed reduced amplitudes in the 80% Pre-Onset condition, an increase for the 120% N2-Onset condition, and monotonic amplitude scaling with stimulation intensity. The N2 component was not affected by TMS. These findings reveal the influence of TMS intensity and timing on visual perception and electrophysiological responses, with optimal facilitation at stimulation intensities below RMT.
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影响因子：
14.5
作者：
BECKERS, G;ZEKI, S
通讯作者：
ZEKI, S
影响因子：
11.2
作者：
Desmond, JE;Chen, SHA;Shich, PB
通讯作者：
Shich, PB
影响因子：
7.7
作者：
Abrahamyan, Arman;Clifford, Colin W. G.;Harris, Justin A.
通讯作者：
Harris, Justin A.
DOI：
10.1016/j.clinph.2017.08.007
发表时间：
2017-11
期刊：
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子：
--
作者：
Hallett M;Di Iorio R;Rossini PM;Park JE;Chen R;Celnik P;Strafella AP;Matsumoto H;Ugawa Y
通讯作者：
Ugawa Y
影响因子：
5.3
作者：
Abrahamyan, Arman;Clifford, Colin W. G.;Harris, Justin A.
通讯作者：
Harris, Justin A.