Thrombin antithrombin complex concentration as an early predictor of deep vein thrombosis after total hip arthroplasty and total knee arthroplasty.
Thrombin antithrombin complex concentration as an early predictor of deep vein thrombosis after total hip arthroplasty and total knee arthroplasty.
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DOI：
10.1186/s12891-022-05532-1
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发表时间：
2022-06-14
影响因子：
2.3
通讯作者：
中科院分区：
文献类型：
--
作者：
全髋关节置换术（THA）/全膝关节置换术（TKA）后静脉血栓栓塞（VTE）的早期预测标志物仍不清楚。我们的研究确定了 THA/TKA 后 VTE 的早期预测标志物。 2020 年 5 月至 2022 年 4 月期间进行了一项单机构回顾性审查研究（n = 256）。所有患者均在术前及术后第7天接受多普勒超声检查。深静脉血栓（DVT）是通过下肢多普勒超声检查发现血栓形成来定义的。在每位患者术前和术后第 1、4、7、14 天测试凝血酶-抗凝血酶复合物 (TAT)、血栓调节蛋白 (TM) 和纤溶酶-抗纤溶酶复合物 (PIC) 浓度。然后通过受试者工作特征 (ROC) 曲线分析获取这些值，并进一步量化浓度的风险水平。术后第1天（pod-1），所有患者的TAT和PIC浓度均显着高于术前（p<<0.05）。 pod-1 DVT 组患者的 TAT 和 PIC 水平显着高于非 DVT 组（p<0.05）。在 pod-1 时，DVT 患者的 TAT 浓度为 49.47ng/mL，而非 DVT 患者为 20.70ng/mL，PIC 为 3.72μg/mL，而非 DVT 患者则为 1.65μg/mL。 ROC曲线分析表明，TAT浓度为24.3ng/mL时，敏感性为87.9%，特异性为69.1%。 pod-1 上的 TAT 水平可以在 THA/TKA 后早期预测 DVT，这使得早期干预降低 DVT 的发生率成为可能。
Early predictive markers of venous thromboembolism (VTE) after total hip arthroplasty (THA)/total knee arthroplasty (TKA) remain unclear. Our study identified early predictive markers for VTE after THA/TKA. A single-institution retrospective review study was conducted between May 2020 and April 2022 (n = 256). All patients underwent Doppler ultrasounds exam in preoperation and seventh day after surgery. Deep vein thrombosis (DVT) was defined by Doppler ultrasound of the lower extremities, which revealed thrombosis. Thrombin-antithrombin complex (TAT), thrombomodulin (TM), and plasmin-antiplasmin complex (PIC) concentration were tested from each patient’s preoperative and postoperative days 1, 4, 7, 14. These values were then accessed via receiver operating characteristic (ROC) curve analysis and further quantified the level of this risk by concentration. On postoperative day 1 (pod-1), all patients’ TAT and PIC concentrations were significantly higher than those preoperatively (p < 0.05). The levels of TAT and PIC in patients in the DVT group on pod-1 were significantly higher than those in the non-DVT group (p < 0.05). At pod-1, the TAT concentration for DVT patients was 49.47 ng/mL compared to 20.70 ng/mL for non-DVT patients, PIC was 3.72μg/mL compared to 1.65μg/mL. ROC curve analysis demonstrated that a TAT concentration of 24.3 ng/mL had a sensitivity of 87.9% and a specificity of 69.1%. TAT levels on pod-1 may predict DVT early after THA/TKA, which makes it possible for early intervention to decrease the incidence of DVT.
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影响因子：
3.8
作者：
Kitayama H;Kondo T;Sugiyama J;Kurimoto K;Nishino Y;Hirayama M;Tsuji Y
通讯作者：
Tsuji Y
影响因子：
2.6
作者：
Mitani G;Takagaki T;Hamahashi K;Serigano K;Nakamura Y;Sato M;Mochida J
通讯作者：
Mochida J
影响因子：
4
作者：
Lippi, Giuseppe;Cervellin, Gianfranco;Favaloro, Emmanuel J.
通讯作者：
Favaloro, Emmanuel J.
影响因子：
4.5
作者：
Cha, Seung-Ick;Lee, Shin-Yeop;Kim, Shin-Yoon
通讯作者：
Kim, Shin-Yoon
影响因子：
2.4
作者：
Abu Assab, Tareq;Raveh-Brawer, David;Ganzel, Chezi
通讯作者：
Ganzel, Chezi