Synovial fluid lubricin increases in spontaneous canine cruciate ligament rupture.
Synovial fluid lubricin increases in spontaneous canine cruciate ligament rupture.
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DOI：
10.1038/s41598-020-73270-2
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发表时间：
2020-10-07
影响因子：
4.6
通讯作者：
Reesink HL
中科院分区：
文献类型：
--
作者：
Wang Y;Gludish DW;Hayashi K;Todhunter RJ;Krotscheck U;Johnson PJ;Cummings BP;Su J;Reesink HL
润滑素是滑液中重要的边界润滑剂和软骨保护糖蛋白。在实验性创伤后骨关节炎（PTOA）动物模型以及人类和动物自然发生的关节损伤中，已经报告了滑液润滑素浓度的增加和减少，但对于润滑素在不同物种或损伤类型中如何改变尚未达成共识。在人类和马的关节内骨折以及人类晚期骨关节炎中观察到滑液润滑素增加;然而，尚不清楚大型动物中膝关节失稳损伤如何影响滑液润滑素。颅侧交叉韧带（RCCL），相当于四足动物的前交叉韧带，是犬常见的损伤，常伴有OA。在这里，临床记录，X线片，并从30只狗持续RCCL和9个临床健康的狗滑液样本进行了分析。与对照关节相比，RCCL关节的滑液润滑素浓度几乎高出16倍，而IL-2、IL-6、IL-8和TNF-α浓度在组间无差异。滑液润滑素浓度与影像学OA的存在相关，并且在OA的影像学表现之前，在三只持续RCCL损伤的动物中升高，表明润滑素可能是早期关节损伤的潜在生物标志物。
Lubricin is an important boundary lubricant and chondroprotective glycoprotein in synovial fluid. Both increased and decreased synovial fluid lubricin concentrations have been reported in experimental post-traumatic osteoarthritis (PTOA) animal models and in naturally occurring joint injuries in humans and animals, with no consensus about how lubricin is altered in different species or injury types. Increased synovial fluid lubricin has been observed following intra-articular fracture in humans and horses and in human late-stage osteoarthritis; however, it is unknown how synovial lubricin is affected by knee-destabilizing injuries in large animals. Spontaneous rupture of cranial cruciate ligament (RCCL), the anterior cruciate ligament equivalent in quadrupeds, is a common injury in dogs often accompanied by OA. Here, clinical records, radiographs, and synovial fluid samples from 30 dogs that sustained RCCL and 9 clinically healthy dogs were analyzed. Synovial fluid lubricin concentrations were nearly 16-fold greater in RCCL joints as compared to control joints, while IL-2, IL-6, IL-8, and TNF-α concentrations did not differ between groups. Synovial fluid lubricin concentrations were correlated with the presence of radiographic OA and were elevated in three animals sustaining RCCL injury prior to the radiographic manifestation of OA, indicating that lubricin may be a potential biomarker for early joint injury.
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影响因子：
--
作者：
Antonacci, Jennifer M.;Schmidt, Tannin A.;Serventi, Lisa A.;Cai, Matthew Z.;Shu, Yuyu L.;Schumacher, Barbara L.;McIlwraith, C. Wayne;Sah, Robert L.
通讯作者：
Sah, Robert L.
影响因子：
4.6
作者：
Iqbal SM;Leonard C;Regmi SC;De Rantere D;Tailor P;Ren G;Ishida H;Hsu C;Abubacker S;Pang DS;Salo PT;Vogel HJ;Hart DA;Waterhouse CC;Jay GD;Schmidt TA;Krawetz RJ
通讯作者：
Krawetz RJ
影响因子：
2.8
作者：
Feeney, Elizabeth;Peal, Bridgette T.;Reesink, Heidi L.
通讯作者：
Reesink, Heidi L.
影响因子：
27.4
作者：
Harty, Leonard C.;Biniecka, Monika;Fearon, Ursula
通讯作者：
Fearon, Ursula
影响因子：
12.7
作者：
Chen D;Shen J;Zhao W;Wang T;Han L;Hamilton JL;Im HJ
通讯作者：
Im HJ