High prevalence and associated risk factors for impaired renal function and urinary abnormalities in a rural adult population from southern China.
High prevalence and associated risk factors for impaired renal function and urinary abnormalities in a rural adult population from southern China.
复制标题
中国南方农村成年人口中肾功能受损和泌尿异常的高患病率及相关危险因素。
DOI：
10.1371/journal.pone.0047100
复制
发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Chen W
中科院分区：
文献类型：
--
作者：
Liu Q;Li Z;Wang H;Chen X;Dong X;Mao H;Tan J;Luo N;Johnson RJ;Chen W;Yu X;Chen W
慢性肾脏病 (CKD) 的患病率已经增加，并将在全球范围内继续增加。然而，有关中国农村地区 CKD 患病率的数据有限。因此，我们调查了中国南方农村成年人口肾功能受损和泌尿异常的患病率和相关危险因素。 2006年12月至2007年1月，采用分层、多阶段抽样技术，随机抽取珠海市四个村庄的20岁以上居民。所有参与者都接受了访谈并测试了血尿、蛋白尿和估计肾小球滤过率（eGFR）。研究了年龄、性别、糖尿病、高血压、高尿酸血症、教育水平和肾损伤指标之间的关联。总体而言，1,214 名受试者参加了这项研究。调整年龄和性别后，蛋白尿患病率为 7.1%（95% CI：4.5，8.1），eGFR 降低为 2.6%（95% CI：1.7%，3.3%），血尿率为 4.6%（95% CI：3.3%，6.0%）。大约 13.6%（95% CI：12.0%、15.1%）的患者至少有一项肾损伤指标，但只有 8.3% 的患者之前意识到。年龄、糖尿病、高脂血症、高血压、高尿酸血症、肾毒性药物的使用、冠心病和 CKD 病史与肾功能受损和泌尿系统异常独立相关。此外，年龄、糖尿病和高血压与蛋白尿独立相关。年龄、高血压、高尿酸血症、中心性肥胖和冠心病与肾功能下降独立相关。该人群肾功能受损和泌尿系统异常的患病率高且认识低，说明迫切需要在中国南方农村地区实施 CKD 预防计划。
The prevalence of chronic kidney disease (CKD) has increased and will continue to rise worldwide. However, data regarding the prevalence of CKD in a rural area of China are limited. We therefore investigated the prevalence and associated risk factors of impaired renal function and urinary abnormalities in an adult rural population in southern China. Between December 2006 and January 2007, residents older than 20 years from four villages in Zhuhai city were randomly selected using a stratified, multistage sampling technique. All participants were interviewed and tested for hematuria, albuminuria and estimated glomerular filtration rate (eGFR). The associations between age, gender, diabetes mellitus, hypertension, hyperuricemia, education level and indicators of renal damage were examined. Overall, 1,214 subjects were enrolled in this study. After adjustment for age and gender, the prevalence of albuminuria was 7.1% (95% CI: 4.5, 8.1), reduced eGFR was 2.6% (95% CI: 1.7%, 3.3%), and hematuria was 4.6% (95% CI: 3.3%, 6.0%). Approximately 13.6% (95% CI: 12.0%, 15.1%) of the patients had at least one indicator of renal damage, but only 8.3% were previously aware. Age, diabetes, hyperlipidemia, hypertension, hyperuricemia, use of nephrotoxic medications, coronary heart disease and history of CKD were independently associated with impaired renal function and urinary abnormalities. Additionally, age, diabetes, and hypertension were independently associated with albuminuria. Age, hypertension, hyperuricemia, central obesity, and coronary heart disease were independently associated with reduced renal function. The high prevalence and low awareness of impaired renal function and urinary abnormalities in this population illustrates the urgent need to implement a CKD prevention program in the rural areas of southern China.
登录
查看更多内容
影响因子：
37.8
作者：
Wu, Yangfeng;Huxley, Rachel;Yang, Xiaoguang
通讯作者：
Yang, Xiaoguang
影响因子：
158.5
作者：
Yang, Wenying;Lu, Juming;He, Jiang
通讯作者：
He, Jiang
影响因子：
2.7
作者：
Sur, Zhaoqing;Zheng, Liqiang;Sun, Yingxian
通讯作者：
Sun, Yingxian
DOI：
10.1097/01.asn.0000070152.11927.4a
发表时间：
2003-07-01
影响因子：
13.6
作者：
Chadban, SJ;Briganti, EM;Atkins, RC
通讯作者：
Atkins, RC
影响因子：
13.2
作者：
Coresh, J;Astor, BC;Levey, AS
通讯作者：
Levey, AS