Amyloid burden correlates with cognitive decline in Alzheimer's disease presenting with aphasia.
Amyloid burden correlates with cognitive decline in Alzheimer's disease presenting with aphasia.
复制标题
DOI：
10.1111/ene.12331
复制
发表时间：
2014-07
影响因子：
5.1
通讯作者：
Josephs KA
中科院分区：
文献类型：
--
作者：
Jung Y;Whitwell JL;Duffy JR;Strand EA;Machulda MM;Senjem ML;Lowe V;Jack CR Jr;Josephs KA
阿尔茨海默病（AD）患者的一个子集存在早期和突出的语言缺陷。目前尚不清楚潜在β-淀粉样蛋白病理学的负担是否与这些受试者的语言或一般认知障碍相关。在此，我们使用回归和相关性分析评估了[11 C]匹兹堡化合物B（PiB）PET上皮质β-淀粉样蛋白负荷与蒙特利尔认知评估（莫卡）、韦氏记忆量表-第三版（WMS-III）、波士顿失语症测验（BNT）和西方失语症成套测验（WAB）表现之间的关系，这些受试者在PiB PET上显示β-淀粉样蛋白沉积。总体PiB比率与莫卡（p = 0.02）和WMS-III视觉再现（VR）子测试（VR I，p = 0.02; VR II，p = 0.04）呈负相关。然而，PiB比率、BNT（p = 0.13）、WAB失语商数（p = 0.11）和WAB重复评分（p = 0.34）之间的相关性不显著。这项研究表明，皮质β-淀粉样蛋白负荷增加与失语症AD患者的认知障碍有关，但与语言障碍无关。结果表明，β-淀粉样蛋白沉积可能部分导致此类患者的认知受损，而语言功能障碍可能受到其他病理机制的影响，可能是β-淀粉样蛋白沉积的下游途径。
A subset of patients with Alzheimer’s disease (AD) present with early and prominent language deficits. It is unclear whether the burden of underlying β-amyloid pathology is associated with language or general cognitive impairment in these subjects. Here, we assess the relationship between cortical β-amyloid burden on [11C]Pittsburgh compound B (PiB) PET and performance on the Montreal Cognitive Assessment (MoCA), the Wechsler Memory Scale-Third Edition (WMS-III), the Boston Naming Test (BNT), and the Western Aphasia Battery (WAB) using regression and correlation analyses in subjects presenting with aphasia that showed β-amyloid deposition on PiB PET. The global PiB ratio was inversely correlated with MoCA (p = 0.02) and the WMS-III Visual Reproduction (VR) subtest (VR I, p = 0.02; VR II, p = 0.04). However, the correlations between PiB ratio, BNT (p = 0.13), WAB aphasia quotient (p = 0.11), and WAB repetition scores (p = 0.34) were not significant. This study demonstrates that an increased cortical β-amyloid burden is associated with cognitive impairment, but not language deficits, in AD subjects presenting with aphasia. The results suggest that β-amyloid deposition may partly contribute to impaired cognition in such patients while language dysfunction may be influenced by other pathologic mechanisms, perhaps downstream pathways of β-amyloid deposition.
登录
查看更多内容
影响因子：
9.9
作者：
Josephs, K. A.;Whitwell, J. L.;Petersen, R. C.
通讯作者：
Petersen, R. C.
影响因子：
11.2
作者：
Villemagne, Victor L.;Pike, Kerryn E.;Chetelat, Gael;Ellis, Kathryn A.;Mulligan, Rachel S.;Bourgeat, Pierrick;Ackermann, Uwe;Jones, Gareth;Szoeke, Cassandra;Salvado, Olivier;Martins, Ralph;O'Keefe, Graeme;Mathis, Chester A.;Klunk, William E.;Ames, David;Masters, Colin L.;Rowe, Christopher C.
通讯作者：
Rowe, Christopher C.
影响因子：
14.5
作者：
Jack, Clifford R., Jr.;Lowe, Val J.;Petersen, Ronald C.
通讯作者：
Petersen, Ronald C.
影响因子：
--
作者：
Perrotin, Audrey;Mormino, Elizabeth C.;Madison, Cindee M.;Hayenga, Amynta O.;Jagust, William J.
通讯作者：
Jagust, William J.