Longitudinal assessment of Aβ and cognition in aging and Alzheimer disease.
Longitudinal assessment of Aβ and cognition in aging and Alzheimer disease.
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DOI：
10.1002/ana.22248
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发表时间：
2011-01
影响因子：
11.2
通讯作者：
Rowe, Christopher C.
中科院分区：
文献类型：
--
作者：
Villemagne, Victor L.;Pike, Kerryn E.;Chetelat, Gael;Ellis, Kathryn A.;Mulligan, Rachel S.;Bourgeat, Pierrick;Ackermann, Uwe;Jones, Gareth;Szoeke, Cassandra;Salvado, Olivier;Martins, Ralph;O'Keefe, Graeme;Mathis, Chester A.;Klunk, William E.;Ames, David;Masters, Colin L.;Rowe, Christopher C.
纵向评估 Aβ 沉积并探讨其与认知和疾病进展的关系。对 206 名受试者进行[11C]匹兹堡化合物 B (PiB) 正电子发射断层扫描后 20 ± 3 个月进行临床随访：35 名患有阿尔茨海默型痴呆 (DAT)，65 名患有轻度认知障碍 (MCI)，以及 106 名年龄匹配的健康对照 (HC)。 185 名受试者在随访时进行了第二次 PiB 扫描，57 名受试者在 3 年后进行了第三次扫描。在基线时，97% 的 DAT、69% 的 MCI 和 31% 的 HC 受试者表现出高 PiB 保留率。在 20 个月的随访中，在 DAT 组和 MCI 组以及基线时 PiB 保留率较高的 HC 中观察到 PiB 标准化摄取值比率虽小但显着增加（分别为 5.7%、2.1% 和 1.5%）。增加与载脂蛋白 E ε4 等位基因的数量有关。当所有组合并时，PiB 增加和认知下降之间存在微弱相关性。高 PiB 的 MCI 受试者中有 67% 进展为 DAT，而 PiB 低的 MCI 受试者中这一比例为 5%，但低 PiB MCI 受试者中有 20% 进展为其他痴呆症。在高 PiB HC 中，16% 的人在 20 个月内出现 MCI 或 DAT，25% 的人在 3 岁时出现 MCI 或 DAT。一位低 PiB HC 开发了 MCI。 Aβ 沉积从认知正常缓慢增加到中等严重程度的 DAT。广泛的 Aβ 沉积先于认知障碍，并与 ApoE 基因型和 HC 认知能力下降以及 1 至 2 年内从 MCI 进展为 DAT 的较高风险相关。然而，认知能力下降与 Aβ 负荷变化的相关性很弱，这表明下游因素对症状进展有更直接的影响。
Assess Aβ deposition longitudinally and explore its relationship with cognition and disease progression. Clinical follow-up was obtained 20 ± 3 months after [11C]Pittsburgh compound B (PiB)-positron emission tomography in 206 subjects: 35 with dementia of the Alzheimer type (DAT), 65 with mild cognitive impairment (MCI), and 106 age-matched healthy controls (HCs). A second PiB scan was obtained at follow-up in 185 subjects and a third scan after 3 years in 57. At baseline, 97% of DAT, 69% of MCI, and 31% of HC subjects showed high PiB retention. At 20-month follow-up, small but significant increases in PiB standardized uptake value ratios were observed in the DAT and MCI groups, and in HCs with high PiB retention at baseline (5.7%, 2.1%, and 1.5%, respectively). Increases were associated with the number of apolipoprotein E ε4 alleles. There was a weak correlation between PiB increases and decline in cognition when all groups were combined. Progression to DAT occurred in 67% of MCI with high PiB versus 5% of those with low PiB, but 20% of the low PiB MCI subjects progressed to other dementias. Of the high PiB HCs, 16% developed MCI or DAT by 20 months and 25% by 3 years. One low PiB HC developed MCI. Aβ deposition increases slowly from cognitive normality to moderate severity DAT. Extensive Aβ deposition precedes cognitive impairment, and is associated with ApoE genotype and a higher risk of cognitive decline in HCs and progression from MCI to DAT over 1 to 2 years. However, cognitive decline is only weakly related to change in Aβ burden, suggesting that downstream factors have a more direct effect on symptom progression.
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影响因子：
158.5
作者：
Petersen, RC;Thomas, RG;Thal, LJ
通讯作者：
Thal, LJ
影响因子：
120.7
作者：
Näslund, J;Haroutunian, V;Buxbaum, JD
通讯作者：
Buxbaum, JD
影响因子：
9.9
作者：
Busse, A.;Hensel, A.;Riedel-Heller, S. G.
通讯作者：
Riedel-Heller, S. G.
影响因子：
11.2
作者：
Klunk, WE;Engler, H;Långström, B
通讯作者：
Långström, B
影响因子：
--
作者：
Aizenstein, Howard Jay;Nebes, Robert D.;Saxton, Judith A.;Price, Julie C.;Mathis, Chester A.;Tsopelas, Nicholas D.;Ziolko, Scott K.;James, Jeffrey A.;Snitz, Beth E.;Houck, Patricia R.;Bi, Wenzhu;Cohen, Ann D.;Lopresti, Brian J.;DeKosky, Steven T.;Halligan, Edythe M.;Klunk, William E.
通讯作者：
Klunk, William E.