Subjective cognition and amyloid deposition imaging: a Pittsburgh Compound B positron emission tomography study in normal elderly individuals.
Subjective cognition and amyloid deposition imaging: a Pittsburgh Compound B positron emission tomography study in normal elderly individuals.
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DOI：
10.1001/archneurol.2011.666
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发表时间：
2012-02
影响因子：
--
通讯作者：
Jagust, William J.
中科院分区：
文献类型：
--
作者：
Perrotin, Audrey;Mormino, Elizabeth C.;Madison, Cindee M.;Hayenga, Amynta O.;Jagust, William J.
主观认知障碍（SCI）作为阿尔茨海默病（AD）的早期临床表现是一个备受争议的中心问题。目的 研究正常老年人主观认知与 AD 神经病理学标志、β 淀粉样蛋白 (Aβ) 沉积之间的关系，采用 [11C]-匹兹堡化合物 B (PiB) - 正电子发射断层扫描 (PET) 成像。横截面分析。包括 48 名认知正常的老年受试者（11 名 PiB 摄取量高，28 名 PiB 摄取量低）。所有患者均接受了临床和神经心理学评估以及 MRI 和 PET 扫描。在情景记忆测量中，高 PiB 受试者的表现明显低于低 PiB 受试者，并且当需要相对于同龄其他人评估自己时，他们对自己的一般记忆能力不太有信心。与客观认知表现相比，高 PiB 组和低 PiB 组的认知自我报告的准确性没有差异。全组的一般记忆自我报告与右侧内侧前额叶皮层 (PFC)/前扣带皮层 (ACC) 和右侧楔前叶/后扣带皮层 (PCC) 的区域 PiB 摄取显着相关。对记忆能力的信心下降与这些大脑区域的 PiB 增加有关。所有结果均独立于人口变量和抑郁影响。我们的研究结果表明，认知正常的老年受试者对记忆能力的自信心下降与 PiB-PET 成像测量的 AD 神经病理学特征有关。讨论了 SCI 在 AD 病理过程早期阶段的相关性。
Subjective cognitive impairment (SCI) as an early clinical manifestation in Alzheimer disease (AD) is a central and highly debated question. To study the relationship between subjective cognition and the neuropathological hallmark of AD, amyloid-beta (Aβ) deposition, imaged with [11C]-Pittsburg compound B (PiB) - positron emission tomography (PET), in normal elderly individuals. Cross-sectional analysis. Forty-eight cognitively normal elderly subjects (11 with high PiB uptake and 28 with low PiB uptake) were included. All underwent clinical and neuropsychological evaluations and MRI and PET scanning. High PiB subjects showed significantly lower performance than low PiB subjects on an episodic memory measure, and were less confident about their general memory abilities when required to evaluate themselves relative to other people of the same age. High and low PiB groups did not differ on the accuracy of their cognitive self-reports compare to objective cognitive performance. General memory self-reports from the whole group were significantly correlated to regional PiB uptake in the right medial prefrontal cortex (PFC)/anterior cingulate cortex (ACC) and in the right precuneus/posterior cingulate cortex (PCC). Reduced confidence about memory abilities was associated with greater PiB in these brain regions. All results are independent of demographic variables and depressive affects. Our findings suggest that a decrease of self-confidence about memory abilities in cognitively normal elderly subjects is related to the neuropathological hallmark of AD measured with PiB-PET imaging. The relevance of SCI in the early stages of the AD pathological process is addressed.
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影响因子：
64.8
作者：
JOACHIM, CL;MORI, H;SELKOE, DJ
通讯作者：
SELKOE, DJ
影响因子：
6.6
作者：
Comijs, HC;Deeg, DJH;Jonker, C
通讯作者：
Jonker, C
影响因子：
2.4
作者：
Duke, LM;Seltzer, B;Vasterling, JJ
通讯作者：
Vasterling, JJ
影响因子：
11.2
作者：
Klunk, WE;Engler, H;Långström, B
通讯作者：
Långström, B
影响因子：
--
作者：
Aizenstein, Howard Jay;Nebes, Robert D.;Saxton, Judith A.;Price, Julie C.;Mathis, Chester A.;Tsopelas, Nicholas D.;Ziolko, Scott K.;James, Jeffrey A.;Snitz, Beth E.;Houck, Patricia R.;Bi, Wenzhu;Cohen, Ann D.;Lopresti, Brian J.;DeKosky, Steven T.;Halligan, Edythe M.;Klunk, William E.
通讯作者：
Klunk, William E.