Bone response to porous alumina implants coated with bioactive materials, observed using different characterization techniques.
Bone response to porous alumina implants coated with bioactive materials, observed using different characterization techniques.
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DOI：
10.5301/jabfm.5000347
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发表时间：
2017-07-27
影响因子：
2.5
通讯作者：
Fortulan CA
中科院分区：
文献类型：
--
作者：
Camilo CC;Silveira CAE;Faeda RS;de Almeida Rollo JMD;Purquerio BM;Fortulan CA
植入物或可植入装置应该比纤维包膜形成更快地整合到宿主组织中，其中接口的设计是最大的挑战之一。一般情况下，生物活性材料不适合承载应用，因此惰性生物材料应运而生。然而，表面必须通过生物活性材料涂层、粗糙度和大小毛孔等技术进行修饰。本研究的目的是验证一种评估涂层生物活性材料的多孔氧化铝种植体上组织生长的方法。用45S5 Bioglass®(BG)和羟基磷灰石(HA)涂层多孔氧化铝种植体，植入大鼠胫骨内，共28天。通过组织学分析、扫描电子显微镜和能量色散X射线能谱(SEM-EDX)线扫描、X线摄影和生物力学测试分析骨结合情况。考虑到种植体与骨组织的结合过程需要加速，因此可以看出，BG启动了快速整合，HA起到了维持这一过程的作用。涂有生物玻璃和HA的惰性材料具有作为骨替代材料的潜力，最好是孔径在100μm到400μm之间，并且限制小于100μm，因为它防止了没有组织形成的毛孔或空洞。设计为功能梯度材料，适用于骨组织在载荷作用下的应用，其中，多孔表面负责骨结合，内部材料承担和传递载荷。
Implants or implantable devices should integrate into the host tissue faster than fibrous capsule formation, in which the design of the interface is one of the biggest challenges. Generally, bioactive materials are not viable for load-bearing applications, so inert biomaterials are proposed. However, the surface must be modified through techniques such as coating with bioactive materials, roughness and sized pores. The aim of this research was to validate an approach for the evaluation of the tissue growth on implants of porous alumina coated with bioactive materials. Porous alumina implants were coated with 45S5 Bioglass® (BG) and hydroxyapatite (HA) and implanted in rat tibiae for a period of 28 days. Ex vivo resections were performed to analyze osseointegration, along with histological analysis, Scanning Electron Microscopy with Energy Dispersive X-Ray spectroscopy (SEM-EDX) line scanning, radiography and biomechanical testing. Given that the process of implant integration needs with the bone tissue to be accelerated, it was then seen that BG acted to start the rapid integration, and HA acted to sustaining the process. Inert materials coated with bioglass and HA present a potential for application as bone substitutes, preferably with pores of diameters between 100 μm and 400 μm and, restrict for smaller than 100 μm, because it prevents pores without organized tissue formation or vacant. Designed as functional gradient material, stand out for applications in bone tissue under load, where, being the porous surface responsible for the osseointegration and the inner material to bear and to transmit the loads.
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影响因子：
5.6
作者：
Clarkin, Claire E.;Emery, Roger J.;Wheeler-Jones, Caroline P. D.
通讯作者：
Wheeler-Jones, Caroline P. D.
DOI：
10.1002/jbm.820280506
发表时间：
1994-05-01
期刊：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
影响因子：
--
作者：
KANGASNIEMI, IMO;VERHEYEN, CCPM;DEGROOT, K
通讯作者：
DEGROOT, K
DOI：
10.1002/jbm.820070328
发表时间：
1973-01-01
期刊：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
影响因子：
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作者：
GRISS, P;ANDRIANW.HV;HEIMKE, G
通讯作者：
HEIMKE, G
DOI：
10.1007/s10856-015-5425-3
发表时间：
2015-02-01
影响因子：
3.7
作者：
Hench, Larry L.
通讯作者：
Hench, Larry L.
DOI：
10.4028/www.scientific.net/kem.309-311.437
发表时间：
2006-01-01
期刊：
BIOCERAMICS 18, PTS 1 AND 2
影响因子：
--
作者：
Kam, MH;Han, JS;Lee, WJ
通讯作者：
Lee, WJ