Ocular abnormalities in a large patient cohort with retinitis pigmentosa in Western China.
Ocular abnormalities in a large patient cohort with retinitis pigmentosa in Western China.
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DOI：
10.1186/s12886-020-01797-z
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发表时间：
2021-01-18
影响因子：
2
通讯作者：
Li S
中科院分区：
文献类型：
--
作者：
Tan L;Long Y;Li Z;Ying X;Ren J;Sun C;Meng X;Li S
To report the prevalence of ocular abnormalities and investigate visual acuity in a large cohort of retinitis pigmentosa (RP) patients in Western China. The medical records and ophthalmic examination reports of 2127 eyes of 1065 RP patients at one eye hospital were retrospectively reviewed to determined the prevalence of ocular abnormalities and the relationship between best corrected visual acuity (BCVA) and macular abnormalities. Nyctalopia (58.2%) and blurred vision (27.1%) were the leading reasons for RP patients to request an ophthalmic examination. BCVA measurements in the better eyes at first clinical presentation showed that 304 patients (28.5%) were categorised as blind and 220 patients (20.7%) as low vision. The most common ocular abnormalities were macular abnormalities (59.7%) and cataracts (43.1%). The macular abnormalities included epiretinal membranes (51.1%), cystoid macular edema (18.4%), vitreomacular traction syndrome (2.4%), macular holes (2.3%) and choroidal neovascular membranes (0.05%). Glaucoma was found in 35 eyes (1.6%). The proportions of epiretinal membranes (p = 0.001) and macular holes (p = 0.008) increased significantly with age. Cystoid macular edema was significantly associated with poorer visual acuity in RP patients with clear lens (p = 0.002). Cataracts and macular abnormalities are common in RP patients. Of the macular abnormalities, cystoid macular edema may have a negative effect on BCVA in RP patients with clear lens. Therefore, optical coherence tomography screening in RP patients is highly recommended for early detection and treatment of maculopathy. The online version contains supplementary material available at 10.1186/s12886-020-01797-z.
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影响因子：
13.7
作者：
Meuer, Stacy M.;Myers, Chelsea E.;Klein, Barbara E. K.;Swift, Maria K.;Huang, Yijun;Gangaputra, Sapna;Pak, Jeong W.;Danis, Ronald P.;Klein, Ronald
通讯作者：
Klein, Ronald
DOI：
10.1097/00006982-199705000-00009
发表时间：
1997-01-01
影响因子：
3.3
作者：
Grover, S;Fishman, GA;Adelman, AE
通讯作者：
Adelman, AE
影响因子：
13.7
作者：
McCannel CA;Ensminger JL;Diehl NN;Hodge DN
通讯作者：
Hodge DN
影响因子：
4.4
作者：
Schulze-Bonsel, K;Feltgen, N;Bach, M
通讯作者：
Bach, M
影响因子：
4.4
作者：
Fujiwara, Kohta;Ikeda, Yasuhiro;Ishibashi, Tatsuro
通讯作者：
Ishibashi, Tatsuro