The epidemiology of vitreoretinal interface abnormalities as detected by spectral-domain optical coherence tomography: the beaver dam eye study.
The epidemiology of vitreoretinal interface abnormalities as detected by spectral-domain optical coherence tomography: the beaver dam eye study.
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DOI：
10.1016/j.ophtha.2014.10.014
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发表时间：
2015-04
期刊：
影响因子：
13.7
通讯作者：
Klein, Ronald
中科院分区：
文献类型：
--
作者：
Meuer, Stacy M.;Myers, Chelsea E.;Klein, Barbara E. K.;Swift, Maria K.;Huang, Yijun;Gangaputra, Sapna;Pak, Jeong W.;Danis, Ronald P.;Klein, Ronald
在一项以老年人为基础的研究中，描述视网膜前膜、玻璃体黄斑牵引、黄斑囊肿、血管旁囊肿、板层黄斑孔、全层黄斑孔和视力障碍的患病率及其相互关系。横断面研究。在2008-2010年为期20年的海狸坝眼科研究随访检查中，有1913名年龄在63-102岁之间的参与者，其中1540人（2980只眼睛）至少有一只眼睛的黄斑进行了可分级的光谱域光学相干断层扫描（SD-OCT）。通过黄斑SD-OCT扫描和三个标准视场照片的标准化分级来确定视网膜前膜和其他视网膜病变的存在。视网膜上膜，玻璃体黄斑牵引，黄斑囊肿，血管旁囊肿，板层黄斑孔，全层黄斑孔和视力障碍。使用SD-OCT估计视网膜前膜（34.1%）、玻璃体黄斑牵拉（1.6%）、黄斑囊肿（5.7%）、血管旁囊肿（20.0%）、板层黄斑孔（3.6%）和全层黄斑孔（0.4%）的患病率。黄斑囊肿（P<0.001）、视网膜前膜（P<0.001）和玻璃体黄斑牵张（P=0.005）的患病率随着年龄的增长而增加，血管旁囊肿（P=0.05）的患病率随着年龄的增长而下降，板层黄斑孔的患病率与年龄无关（P=0.70）。有白内障手术史者，黄斑囊肿、板状黄斑孔及视网膜前膜的患病率较高。黄斑囊肿和视网膜前膜在有增生性糖尿病视网膜病变、视网膜静脉阻塞和视网膜脱离等视网膜疾病的眼睛中比在没有这些疾病的眼睛中更常见。黄斑囊肿、视网膜前膜和全层黄斑孔与视力损害有关。在调整年龄和性别后，有视网膜前膜的眼睛比没有视网膜前膜的眼睛更容易发生黄斑囊肿（比值比[OR] 3.96， P<0.0001）、血管旁囊肿（比值比[OR] 1.45， P=0.007）、板层黄斑孔（比值比[OR] 10.62， P<0.001）、玻璃体黄斑牵拉（比值比[OR] 2.72， P=0.01）和视力障碍（比值比[OR] 3.23， P<0.001）。视网膜上膜与黄斑囊肿、血管旁囊肿、板层黄斑孔、玻璃体黄斑牵拉和视力障碍有关。进一步的随访将有助于更好地了解视网膜前膜和玻璃体黄斑牵引的自然历史及其与老年人黄斑囊肿和板层黄斑孔发展的关系。
To describe the prevalence and interrelationships of epiretinal membranes, vitreomacular traction, macular cysts, paravascular cysts, lamellar macular holes, full-thickness macular holes, and visual impairment in a population-based study of older adults. Cross-sectional study. There were 1913 participants aged 63–102 years at the 20-year Beaver Dam Eye Study follow-up examination in 2008–2010, of whom 1540 (2980 eyes) had gradable spectral-domain optical coherence tomography (SD-OCT) scans of the macula in at least one eye. The presence of epiretinal membranes and other retinal lesions was determined by standardized grading of macular SD-OCT scans and photographs of three standard fields. Epiretinal membranes, vitreomacular traction, macular cysts, paravascular cysts, lamellar macular holes, full-thickness macular holes, and visual impairment. Using SD-OCT the prevalences of epiretinal membranes (34.1%), vitreomacular traction (1.6%), macular cysts (5.7%), paravascular cysts (20.0%), lamellar macular holes (3.6%), and full-thickness macular holes (0.4%) were estimated. The prevalences of macular cysts (P<0.001), epiretinal membranes (P<0.001), and vitreomacular traction (P=0.005) increased with age, the prevalence of paravascular cysts (P=0.05) decreased with age, and the prevalence of lamellar macular holes was not associated with age (P=0.70). The prevalences of macular cysts, lamellar macular holes, and epiretinal membranes were higher in eyes with a history of cataract surgery. Macular cysts and epiretinal membranes were more common in eyes with retinal diseases such as proliferative diabetic retinopathy, retinal vein occlusion, and retinal detachment than in eyes without these conditions. Macular cysts, epiretinal membranes, and full-thickness macular holes were associated with visual impairment. While adjusting for age and sex, macular cysts (odds ratio [OR] 3.96; P<0.0001), paravascular cysts (OR 1.45, P=0.007), lamellar macular holes (OR 10.62; P<0.001), vitreomacular traction (OR 2.72, P=0.01) and visual impairment (OR 3.23; p<0.001) were more frequent in eyes with epiretinal membranes compared to eyes without. Epiretinal membranes are associated with macular cysts, paravascular cysts, lamellar macular holes, vitreomacular traction, and visual impairment. Further follow-up will allow better understanding of the natural history of epiretinal membranes and vitreomacular traction and their relationships to the development of macular cysts and lamellar macular holes in the aging population.
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影响因子：
13.7
作者：
Klein, R;Klein, BEK;Lee, KE
通讯作者：
Lee, KE
影响因子：
4.2
作者：
Chuo, Jean Y.;Lee, Tracy Y. Y.;Maberley, David A. L.
通讯作者：
Maberley, David A. L.
影响因子：
4.4
作者：
Sigler, Eric J.
通讯作者：
Sigler, Eric J.
影响因子：
4.2
作者：
Otani, T;Kishi, S;Maruyama, Y
通讯作者：
Maruyama, Y
影响因子：
4.2
作者：
Klein, Ronald;Klein, Barbara E. K.;Gangnon, Ronald E.
通讯作者：
Gangnon, Ronald E.