TLR7 Modulated T Cell Response in the Mesenteric Lymph Node of Schistosoma japonicum-Infected C57BL/6 Mice
TLR7 Modulated T Cell Response in the Mesenteric Lymph Node of Schistosoma japonicum-Infected C57BL/6 Mice
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TLR7 调节日本血吸虫感染的 C57BL/6 小鼠肠系膜淋巴结中的 T 细胞反应
DOI：
10.1155/2019/2691808
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发表时间：
2019-12
影响因子：
4.1
通讯作者：
Jun Huang
中科院分区：
文献类型：
--
作者：
Jiale Qu;Xiuxue Yu;Chenxi Jin;Yuanfa Feng;Shihao Xie;Hongyan Xie;Quan Yang;Yanwei Qi;Huaina Qiu;Hongyuan Chen;Jianbing Mu;Yi Zhou;Jun Huang
Toll-like receptors (TLRs) play an important role in regulating immune responses during pathogen infection. However, roles of TLRs on T cells reside in the mesenteric lymph node (MLN) were not be fully elucidated in the course of S. japonicum infection. In this study, T lymphocytes from the mesenteric lymph node (MLN) of S. japonicum-infected mice were isolated and the expression and roles of TLR2, TLR3, TLR4, and TLR7 on both CD4+ and CD8+ T cells were compared. We found that the expression of TLR7 was increased in the MLN cells of S. japonicum-infected mice, particularly in CD4+ and CD8+ T cells (P < 0.05). R848, a TLR7 agonist, could enhance the production of IFN-γ from MLN T cells of infected mice (P < 0.05), especially in CD8+ T cells (P < 0.01). In TLR7 gene knockedout (KO) mice, the S. japonicum infection caused a significant decrease (P < 0.05) of the expression of CD25 and CD69, as well as the production of IFN-γ and IL-4 inducted by PMA plus ionomycin on both CD4+ and CD8+ T cells. Furthermore, the decreased level of IFN-γ and IL-4 in the supernatants of SEA- or SWA-stimulated mesenteric lymphocytes was detected (P < 0.05). Our results indicated that S. japonicum infection could induce the TLR7 expression on T cells in the MLN of C57BL/6 mice, and TLR7 mediates T cell response in the early phase of infection.
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影响因子：
5.5
作者：
Susan van Aalst;M. A. Jansen;I. Ludwig;R. van der Zee;W. van Eden;F. Broere
通讯作者：
Susan van Aalst;M. A. Jansen;I. Ludwig;R. van der Zee;W. van Eden;F. Broere
日本血吸虫可溶性卵抗原诱导肝星状细胞凋亡并抑制肝星状细胞活化：可能的分子机制
影响因子：
4
作者：
Duan, Yinong;Gu, Xijuan;He, Xingxin
通讯作者：
He, Xingxin
影响因子：
2
作者：
Luo, Xueping;Xie, Hongyan;Huang, Jun
通讯作者：
Huang, Jun
DOI：
10.1093/ecco-jcc/jjy136
发表时间：
2019-01-01
期刊：
Journal of Crohn's & colitis
影响因子：
--
作者：
Kiernan MG;Coffey JC;McDermott K;Cotter PD;Cabrera-Rubio R;Kiely PA;Dunne CP
通讯作者：
Dunne CP
影响因子：
6
作者：
Lee SM;Joo YD;Seo SK
通讯作者：
Seo SK