A biodegradable antibiotic delivery system based on poly-(trimethylene carbonate) for the treatment of osteomyelitis.
A biodegradable antibiotic delivery system based on poly-(trimethylene carbonate) for the treatment of osteomyelitis.
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DOI：
10.3109/17453670903350040
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发表时间：
2009-10
影响因子：
3.7
通讯作者：
Grijpma DW
中科院分区：
文献类型：
--
作者：
Neut D;Kluin OS;Crielaard BJ;van der Mei HC;Busscher HJ;Grijpma DW
背景和目的许多关于可生物降解材料作为局部药物递送抗生素载体的研究都是基于聚丙交酯。然而，由于植入部位的骨再生能力较差，聚丙交酯植入物在骨中的使用一直存在争议。聚（三亚甲基碳酸酯）（PTMC）是一种可酶降解的聚合物，不会产生酸性降解产物。我们探讨了 PTMC 作为抗生素释放聚合物用于骨髓炎局部治疗的适用性。方法 本研究探讨了 PTMC 的 2 个不同属性：(1) 负载庆大霉素的 PTMC 的释放动力学和 (2) 其抑制生物膜形成的行为。将这两个特性与市售的载有庆大霉素的聚甲基丙烯酸甲酯（PMMA）珠进行了比较，后者常用于骨髓炎的局部治疗。结果 在模拟体内情况的脂肪酶溶液中，掺有庆大霉素的 PTMC 圆片因表面侵蚀而降解，并在 14 天内释放出 60% 的庆大霉素。这与临床使用的 PMMA 珠释放的庆大霉素类似。此外，在负载庆大霉素的 PTMC 盘存在的情况下，金黄色葡萄球菌的生物膜形成在至少 14 天内被抑制约 80%。这与负载庆大霉素的 PMMA 珠的效果相似。在没有脂肪酶的情况下，PTMC 盘的表面侵蚀不会发生，并且庆大霉素的释放和生物膜抑制受到限制。解释 由于负载庆大霉素的 PTMC 圆片表现出与负载庆大霉素的 PMMA 珠相似的抗生素释放特性和生物膜抑制特性，因此 PTMC 似乎是骨髓炎局部治疗中很有前途的可生物降解载体。
Background and purpose Many investigations on biodegradable materials acting as an antibiotic carrier for local drug delivery are based on poly(lactide). However, the use of poly(lactide) implants in bone has been disputed because of poor bone regeneration at the site of implantation. Poly(trimethylene carbonate) (PTMC) is an enzymatically degradable polymer that does not produce acidic degradation products. We explored the suitability of PTMC as an antibiotic releasing polymer for the local treatment of osteomyelitis. Methods This study addressed 2 separate attributes of PTMC: (1) the release kinetics of gentamicin-loaded PTMC and (2) its behavior in inhibiting biofilm formation. Both of these characteristics were compared with those of commercially available gentamicin-loaded poly(methylmethacrylate) (PMMA) beads, which are commonly used in the local treatment of osteomyelitis. Results In a lipase solution that mimics the in vivo situation, PTMC discs with gentamicin incorporated were degraded by surface erosion and released 60% of the gentamicin within 14 days. This is similar to the gentamicin release from clinically used PMMA beads. Moreover, biofilm formation by Staphylococcus aureus was inhibited by approximately 80% over at least 14 days in the presence of gentamicin-loaded PTMC discs. This is similar to the effect of gentamicin-loaded PMMA beads. In the absence of the lipase, surface erosion of PTMC discs did not occur and gentamicin release and biofilm inhibition were limited. Interpretation Since gentamicin-loaded PTMC discs show antibiotic release characteristics and biofilm inhibition characteristics similar to those of gentamicin-loaded PMMA beads, PTMC appears to be a promising biodegradable carrier in the local treatment of osteomyelitis.
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影响因子：
14.2
作者：
Klemm, K
通讯作者：
Klemm, K
DOI：
10.1097/01.blo.0000144477.43661.59
发表时间：
2004-10-01
影响因子：
4.2
作者：
Haleem, AA;Rouse, MS;Patel, R
通讯作者：
Patel, R
影响因子：
4.9
作者：
Koort, Jyri K.;Suokas, Esa;Aro, Hannu T.
通讯作者：
Aro, Hannu T.
影响因子：
3.3
作者：
ZHANG, XC;WYSS, UP;GOOSEN, MFA
通讯作者：
GOOSEN, MFA
影响因子：
4.9
作者：
Mader, JT;Calhoun, J;Cobos, J
通讯作者：
Cobos, J