Semantic association investigated with functional MRI and independent component analysis.
Semantic association investigated with functional MRI and independent component analysis.
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DOI：
10.1016/j.yebeh.2010.11.010
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发表时间：
2011-04
期刊：
影响因子：
--
通讯作者：
Szaflarski JP
中科院分区：
文献类型：
--
作者：
Kim KK;Karunanayaka P;Privitera MD;Holland SK;Szaflarski JP
语义关联是人类语言的重要组成部分，它使话语和推理得以实现。神经影像学研究揭示了语义电路的定位和侧化，对认知神经科学做出了重大贡献。然而，由于方法上的限制，这些调查只确定了单个功能组件，而不是捕获整个网络的行为。为了克服这些限制，我们实施了群体独立成分分析（ICA）来研究健康成人执行fMRI语义决策任务时使用的认知模块。与标准GLM分析的结果相比，ICA检测到几个辅助语义决策的额外大脑区域。鉴定出8个任务相关组ICA图，包括左侧额下回（BA44/45）、中颞后回（BA39/22）、角回/顶叶下小叶（BA39/40）、扣带后回（BA30）、双侧舌回（BA18/23）、额下回（L>R, BA47）、海马与海马旁回（L>R, BA35/36）和扣带前回（BA32/24）。虽然大多数成分都是双侧的，但我们发现了一个单一的、高度左偏化的成分，包括额下回、内侧和颞上回、角回和边缘上回以及顶叶下皮层。这些空间独立的ICA组件的存在意味着功能连接，并且可以等同于它们的模块化。这些结果在生物学上合理的理论模型框架内进行分析和呈现，为右半球或左半球癫痫患者的类似分析做准备。
Semantic association, an essential element of human language, enables discourse and inference. Neuroimaging studies have revealed localization and lateralization of semantic circuitry making substantial contributions to cognitive neuroscience. However, due to methodological limitations, these investigations have only identified individual functional components rather than capturing the behavior of the entire network. To overcome these limitations, we have implemented group independent component analysis (ICA) to investigate the cognitive modules used by healthy adults performing fMRI semantic decision task. When compared to the results of a standard GLM analysis, ICA detected several additional brain regions subserving semantic decision. Eight task-related group ICA maps were identified including left inferior frontal gyrus (BA44/45), middle posterior temporal gyrus (BA39/22), angular gyrus/inferior parietal lobule (BA39/40), posterior cingulate (BA30), bilateral lingual gyrus (BA18/23), inferior frontal gyrus (L>R, BA47), hippocampus with parahippocampal gyrus (L>R, BA35/36) and anterior cingulate (BA32/24). While most of the components were represented bilaterally, we found a single, highly left-lateralized component that included the inferior frontal gyrus and the medial and superior temporal gyri, the angular and supramarginal gyri and the inferior parietal cortex. The presence of these spatially independent ICA components implies functional connectivity and can be equated with their modularity. These results are analyzed and presented in the framework of a biologically plausible theoretical model in preparation for similar analyses in patients with right- or left-hemispheric epilepsies.
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影响因子：
5.7
作者：
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10.1073/pnas.0903525106
发表时间：
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