In-vivo imaging of targeting and modulation of depression-relevant circuitry by transcranial direct current stimulation: a randomized clinical trial.
In-vivo imaging of targeting and modulation of depression-relevant circuitry by transcranial direct current stimulation: a randomized clinical trial.
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经颅直流电刺激靶向和调节抑郁相关回路的体内成像：一项随机临床试验。
DOI：
10.1038/s41398-021-01264-3
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发表时间：
2021-02-24
影响因子：
6.8
通讯作者：
Narr KL
中科院分区：
文献类型：
--
作者：
Jog MS;Kim E;Anderson C;Kubicki A;Kayathi R;Jann K;Yan L;Leaver A;Hellemann G;Iacoboni M;Woods RP;Wang DJJ;Narr KL
最近的经颅直流电刺激（tDCS）治疗抑郁症的临床试验显示出相反的结果。因此，我们使用体内神经影像来确认经颅直流电刺激（tDCS）对抑郁症相关神经回路的靶向和调节。抑郁症参与者（N = 66，基线汉密尔顿抑郁量表 (HDRS) 17 项评分≥14 和 <24）采用双盲、平行设计随机分为主动/假手术组和高清 (HD)/传统 (Conv) tDCS 组，并分别接受针对左背外侧前额叶皮层 (DLPFC) 的 tDCS。根据安培定律，假设 tDCS 电流会在刺激目标处感应磁场，并使用双回波回波平面成像 (DE-EPI) MRI 实时测量。此外，tDCS 治疗试验（包括 12 次每日 20 分钟的疗程）被假设可诱导治疗后 DLPFC 目标和相互连接的前扣带皮层 (ACC) 的脑血流量 (CBF) 变化，使用伪连续动脉自旋标记 (pCASL) MRI 进行测量。对于两个主动刺激蒙太奇，在左侧 DLPFC 目标处观察到显着的 tDCS 电流感应磁场（布罗德曼面积 (BA) 46：pHD = 0.048，Cohen dHD = 0.73；pConv = 0.018，dConv = 0.86；BA 9： pHD = 0.011，dHD = 0.92；pConv = 0.022，dConv = 0.83）。 (a) 在两个活动蒙太奇的左侧 DLPFC 刺激目标处观察到显着的纵向 CBF 增加 (pHD = 3.5E−3, dHD = 0.98; pConv = 2.8E−3, dConv = 1.08), 和 (b) 仅在 HD 蒙太奇的 ACC 处观察到显着的纵向 CBF 增加（pHD = 2.4E−3，dHD = 1.06；pConv = 0.075，dConv = 0.64）。这些结果证实，tDCS 治疗 (a) 涉及刺激目标，(b) 调节抑郁参与者的抑郁相关神经回路，并通过 HD 蒙太奇诱导更强的网络调节。虽然不是主要结果，但主动 HD-tDCS 相对于假手术显示快感缺乏显着改善，尽管治疗后蒙太奇之间的 HDRS 评分没有显着差异。
Recent clinical trials of transcranial direct current stimulation (tDCS) in depression have shown contrasting results. Consequently, we used in-vivo neuroimaging to confirm targeting and modulation of depression-relevant neural circuitry by tDCS. Depressed participants (N = 66, Baseline Hamilton Depression Rating Scale (HDRS) 17-item scores ≥14 and <24) were randomized into Active/Sham and High-definition (HD)/Conventional (Conv) tDCS groups using a double-blind, parallel design, and received tDCS individually targeted at the left dorsolateral prefrontal cortex (DLPFC). In accordance with Ampere’s Law, tDCS currents were hypothesized to induce magnetic fields at the stimulation-target, measured in real-time using dual-echo echo-planar-imaging (DE-EPI) MRI. Additionally, the tDCS treatment trial (consisting of 12 daily 20-min sessions) was hypothesized to induce cerebral blood flow (CBF) changes post-treatment at the DLPFC target and in the reciprocally connected anterior cingulate cortex (ACC), measured using pseudo-continuous arterial spin labeling (pCASL) MRI. Significant tDCS current-induced magnetic fields were observed at the left DLPFC target for both active stimulation montages (Brodmann’s area (BA) 46: pHD = 0.048, Cohen’s dHD = 0.73; pConv = 0.018, dConv = 0.86; BA 9: pHD = 0.011, dHD = 0.92; pConv = 0.022, dConv = 0.83). Significant longitudinal CBF increases were observed (a) at the left DLPFC stimulation-target for both active montages (pHD = 3.5E−3, dHD = 0.98; pConv = 2.8E−3, dConv = 1.08), and (b) at ACC for the HD-montage only (pHD = 2.4E−3, dHD = 1.06; pConv = 0.075, dConv = 0.64). These results confirm that tDCS-treatment (a) engages the stimulation-target, and (b) modulates depression-relevant neural circuitry in depressed participants, with stronger network-modulations induced by the HD-montage. Although not primary outcomes, active HD-tDCS showed significant improvements of anhedonia relative to sham, though HDRS scores did not differ significantly between montages post-treatment.
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影响因子：
5.7
作者：
Edwards, Dylan;Cortes, Mar;Datta, Abhishek;Minhas, Preet;Wassermann, Eric M.;Bikson, Marom
通讯作者：
Bikson, Marom
影响因子：
5.1
作者：
Beeli, Gian;Casutt, Gianclaudio;Jaencke, Lutz
通讯作者：
Jaencke, Lutz
DOI：
10.1109/embc.2012.6346036
发表时间：
2012
期刊：
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
影响因子：
--
作者：
Caparelli-Daquer EM;Zimmermann TJ;Mooshagian E;Parra LC;Rice JK;Datta A;Bikson M;Wassermann EM
通讯作者：
Wassermann EM
影响因子：
7.8
作者：
Dell'Osso, B.;Zanoni, S.;Altamura, A. C.
通讯作者：
Altamura, A. C.
影响因子：
6.6
作者：
Ferrucci, R.;Bortolomasi, M.;Priori, A.
通讯作者：
Priori, A.