Expression of transient receptor potential channel vanilloid (TRPV) 1–4, melastin (TRPM) 5 and 8, and ankyrin (TRPA1) in the normal and methimazole-treated mouse olfactory epithelium.
Expression of transient receptor potential channel vanilloid (TRPV) 1–4, melastin (TRPM) 5 and 8, and ankyrin (TRPA1) in the normal and methimazole-treated mouse olfactory epithelium.
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DOI：
10.3109/00016489.2010.489573
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发表时间：
2010-11
影响因子：
1.4
通讯作者：
Hirakawa K
中科院分区：
文献类型：
--
作者：
Nakashimo Y;Takumida M;Fukuiri T;Anniko M;Hirakawa K
结论：这表明TRPV 1，2，3和4，TRPM 5和8，TRPA 1可能在嗅上皮（OE）中发挥多种作用，有助于嗅觉化学感觉，嗅觉适应，嗅觉三叉神经相互作用和OE流体稳态。在嗅觉障碍患者中，TRPV 1和TRPM 8可能与咖喱和薄荷醇气味的高识别率密切相关，而TRPV 2也可能在嗅觉受体神经元的再生中发挥关键作用。目的：分析TRPV 1 -4、TRPM 5和8以及TRPA 1在正常和甲巯咪唑处理的小鼠OE中的表达。研究方法：通过免疫组织化学方法研究TRPV 1 -4、TRPM 5和8以及TRPA 1在正常和甲巯咪唑处理的CBA/J小鼠OE中的定位。结果：正常OE对TRPV 1 -4、TRPM 5和8及TRPA 1呈阳性反应。在固有层中，神经纤维显示TRPV 1、2和3，TRPM 8和TRPA 1。在病理状态下，TRPV 3、TRPV 4、TRPM 5和TRPA 1的表达显著降低，并且需要很长时间才能恢复。与此相反，TRPM 8的表达几乎没有受到影响，即使在病理条件下，而TRPV 1和TRPV 2表现出早期恢复他巴唑治疗后。
Conclusion: It is suggested that TRPV1, 2, 3, and 4, TRPM5 and 8, and TRPA1 may play several roles in the olfactory epithelium (OE), contributing to olfactory chemosensation, olfactory adaptation, olfactory-trigeminal interaction, and OE fluid homeostasis. In patients with olfactory disturbance, TRPV1 and TRPM8 may be closely related to a high rate of recognition of curry and menthol odors, while TRPV2 may also play a crucial role in the regeneration of olfactory receptor neurons. Objective: Expression of TRPV1–4, TRPM5 and 8, and TRPA1 in the normal and methimazole-treated mouse OE was analyzed. Methods: The localization of TRPV1–4, TRPM5 and 8, and TRPA1 in the OE of normal and methimazole-treated CBA/J mice was investigated by immunohistochemistry. Results: Normal OE showed a positive immunofluorescent reaction to TRPV1–4, TRPM5 and 8, and TRPA1. In lamina propria, the nerve fibers displayed TRPV 1, 2, and 3, TRPM8 and TRPA1. In the pathological condition, the expression of TRPV3, TRPV4, TRPM5, and TRPA1 was markedly reduced and took a long time to recover. In contrast, expression of TRPM8 was scarcely affected, even in the pathological condition, while TRPV1 and TRPV2 showed early recovery following methimazole treatment.
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影响因子：
16.2
作者：
Colburn, Raymond W.;Lubin, Mary Lou;Qin, Ning
通讯作者：
Qin, Ning
影响因子：
--
作者：
Ablimit, A;Matsuzaki, T;Takata, K
通讯作者：
Takata, K
影响因子：
2.4
作者：
Damann, Nils;Rothermel, Markus;Wetzel, Christian H.
通讯作者：
Wetzel, Christian H.
影响因子：
23.4
作者：
Streng, Tomi;Axelsson, Helena E.;Zygmunt, Peter M.
通讯作者：
Zygmunt, Peter M.
影响因子：
3.5
作者：
Laska, M;Distel, H;Hudson, R
通讯作者：
Hudson, R