The cross-sectional association between mean corpuscular volume level and cognitive function in Chinese over 45 years old: Evidence from the China Health and Retirement Longitudinal Study.
The cross-sectional association between mean corpuscular volume level and cognitive function in Chinese over 45 years old: Evidence from the China Health and Retirement Longitudinal Study.
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DOI：
10.1371/journal.pone.0243227
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发表时间：
2020
期刊：
影响因子：
3.7
通讯作者：
Wan Z
中科院分区：
文献类型：
--
作者：
Chen Y;Ma CN;Luo L;Yin J;Gao Z;Yu Z;Wan Z
较少的研究集中在平均红细胞体积（MCV）和认知能力之间的独立关联。本研究的目的是在中国健康与退休纵向研究（CHARLS）的大样本中国居民（年龄≥45岁）中描述MCV和认知表现之间的横截面关联。共有4023名男性和4173名女性MCV ≥ 80 fl的成年人被纳入分析。多元线性回归分析表明，总体认知功能和情景记忆与MCV水平呈显著负相关。当按性别调整时，只有在男性受试者中，较高的MCV水平与整体认知功能、情景记忆和精神状态评分降低相关。通过二元Logistic回归分析，MCV水平越高，（MCV>100 fl）与总体认知功能差相关（OR = 1.601; 95%CI = 1.198-2.139; p = 0.001），情景记忆（OR = 1.679; 95% CI = 1.281-2.201; p<0.001）和精神状态（OR = 1.422; 95% CI = 1.032-1.959; p = 0.031）。当按性别检验这种关联时，在男性和女性中均观察到较高的MCV水平与较差的情景记忆之间的显著关系，（OR = 1.690; 95% CI = 1.211-2.358; p = 0.002）和女性（OR = 1.729; 95%CI = 1.079-2.770; p = 0.023）受试者;而较高的MCV水平与较差的整体认知功能之间的相关性（OR = 1.885; 95% CI = 1.329，2.675; p<0.001）和精神状态（OR = 1.544; 95% CI = 1.034，2.306; p = 0.034）仅在男性受试者中存在。进一步的研究是必要的，以澄清MCV水平和认知性能之间的关系，考虑到性别的横向和纵向考虑。
Fewer studies have focused on the independent association between mean corpuscular volume (MCV) and cognitive performance. This study was designed to characterize the cross-sectional association between MCV and cognitive performance in a large sample of Chinese residents (age≥45 years) from the China Health and Retirement Longitudinal Study (CHARLS). A total of 4023 male and 4173 female adults with MCV ≥ 80 fl were included for analysis. By multivariable linear regression analysis, for the total subjects, MCV level was significantly negatively associated with global cognitive function and episodic memory. When adjusted by sex, only in male subjects, higher MCV level was associated with reduced scores for global cognitive function, episodic memory and mental status. Via binary logistic regression analysis, the higher MCV level (MCV>100 fl) was associated with poor global cognitive function (OR = 1.601; 95% CI = 1.198–2.139; p = 0.001), episodic memory (OR = 1.679; 95% CI = 1.281–2.201; p<0.001), and mental status (OR = 1.422; 95% CI = 1.032–1.959; p = 0.031) for the whole participants. When testing this association by sex, the significant relationship between higher MCV level with worse episodic memory was observed both in male (OR = 1.690; 95% CI = 1.211–2.358; p = 0.002) and female (OR = 1.729; 95% CI = 1.079–2.770; p = 0.023) subjects; while the association between higher MCV level and poor global cognitive function (OR = 1.885; 95% CI = 1.329, 2.675; p<0.001) and mental status (OR = 1.544; 95% CI = 1.034, 2.306; p = 0.034) only existed in male subjects. Further studies are warranted to clarify the association between MCV level and cognitive performance by considering sex into consideration both cross-sectionally and longitudinally.
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