Extending the understanding of leukotrienes in asthma
Extending the understanding of leukotrienes in asthma
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扩展对白三烯在哮喘中的作用的认识
DOI：
10.1097/00130832-200302000-00010
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发表时间：
2003
影响因子：
2.8
通讯作者：
M. Peters
中科院分区：
文献类型：
--
作者：
M. Coffey;M. Peters
综述目的白三烯修饰剂在哮喘治疗中的应用已得到认可。这篇综述的目的是把最近的研究结果，扩大我们对半胱氨酸白三烯的合成和作用在哮喘和变应性疾病的发病机制的理解。最近的发现先前的文献表明，辅助性T 2型细胞因子被认为有利于哮喘和过敏性疾病上调白三烯合成。最近的研究表明，白细胞介素-4和-13也上调半胱氨酸白三烯1受体的表达。相反，白三烯对细胞因子表达的调节也已被探索：半胱氨酸白三烯上调2型细胞因子表达，降低1型细胞因子表达，有利于过敏表型。白三烯形成酶表达的遗传决定因素包括5-脂氧合酶和LTC4合成酶启动子的多态性。白三烯的新作用继续被认识，白三烯在慢性哮喘气道重塑发展中的作用被讨论。越来越多的证据表明白三烯与病毒感染后哮喘的发病机制有关。最后，综述了白三烯在体内测定的研究进展。白三烯及其受体在哮喘发病中起重要作用。我们对这些脂质介质的合成和作用的理解的进展为适当利用白三烯修饰剂和在哮喘的临床管理中设想新的基于白三烯的治疗方法提供了科学依据。
Purpose of reviewLeukotriene modifiers have recognized utility in the management of asthma. The aim of this review is to put into context recent research findings that extend our understanding of cysteinyl leukotriene synthesis and actions in the pathogenesis of asthma and allergic disease. Recent findingsPrevious literature has shown that T helper type 2 cytokines thought to favor asthma and allergic diseases upregulate leukotriene synthesis. Recent findings show that interleukins-4 and -13 also upregulate cysteinyl leukotriene 1 receptor expression. Conversely, the regulation of cytokine expression by leukotrienes has also been explored: cysteinyl leukotrienes upregulate type 2 cytokine expression and decrease type 1 cytokine expression, favoring an allergic phenotype. Genetic determinants of the expression of leukotriene-forming enzymes include polymorphisms of the 5-lipoxygenase and LTC4 synthase promoters. Novel actions of leukotrienes continue to be recognized, and a role for leukotrienes in the development of airway remodeling accompanying chronic asthma is discussed. Mounting evidence implicates leukotrienes in the pathogenesis of asthma following viral infections. Finally, advances in the measurement of leukotrienes in vivo are reviewed. SummaryLeukotrienes and their receptors play an important role in the pathogenesis of asthma. Advances in our understanding of the synthesis and actions of these lipid mediators provide the scientific rationale for appropriate utilization of leukotriene modifiers and for envisioning novel leukotriene-based therapeutic approaches in the clinical management of asthma.
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编码白三烯 C4 合酶的基因的 5 侧翼区域多态性与美国阿司匹林不耐受的哮喘表型无关。
DOI：
10.1067/mai.2000.107603
发表时间：
2000
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
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DOI：
10.1164/ajrccm.164.11.2008137
发表时间：
2001
期刊：
American journal of respiratory and critical care medicine.
影响因子：
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作者：
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DOI：
10.1152/ajplung.00323.2001
发表时间：
2002
期刊：
American journal of physiology. Lung cellular and molecular physiology
影响因子：
--
作者：
Wedde-Beer,Katrin;Hu,Chengping;Rodriguez,MariaM;Piedimonte,Giovanni
通讯作者：
Piedimonte,Giovanni
DOI：
10.1164/ajrccm.165.2.2104050
发表时间：
2002-01-15
影响因子：
24.7
作者：
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通讯作者：
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DOI：
10.1164/ajrccm.165.1.2105051
发表时间：
2002-01-01
影响因子：
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作者：
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通讯作者：
Chi, EY